Evidence map›Paper›PMID 35295713›Full record

ArticleCurrent developments in nutrition2022

Feeding Practice and Delivery Mode Are Determinants of Vitamin K in the Infant Gut: An Exploratory Analysis.

Jessie L Ellis, Mei Wang, Xueyan Fu, Christopher J Fields, Sharon M Donovan, Sarah L Booth

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Current developments in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03341858 (STRONG Kids 2), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03341858 active not recruitingnot on this map

STRONG Kids 2: A Cells-to-Society Approach to Nutrition in Early Childhood

TypeobservationalSponsorUniversity of Illinois at Urbana-ChampaignRan2013 to 2029Enrolled450ConditionsChild Obesity, Child, OnlyArmsno intervention-strictly observational
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Nutritional Status and Nutrient Intake of Children With Feeding Disorders in Early Childhood.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jessie L EllisJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Mei WangDepartment of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID https://orcid.org/0000-0003-0379-6633
Xueyan FuJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Christopher J FieldsHigh Performance Biological Computing Center, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Sharon M DonovanDepartment of Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID https://orcid.org/0000-0002-9785-4189
Sarah L BoothJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID https://orcid.org/0000-0002-1525-4025
Tufts University · USUniversity of Illinois Urbana-Champaign · US

Funding

Dietary and microbial predictors of childhood obesity riskR01DK107561 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHAPKIN, ROBERT STEPHEN, DONOVAN, SHARON MARIE · 2017 to 2021
$2.8M
NIDDK NIH HHS R01 DK107561
6 · The paper itself

Abstract

Background: Infants have low stores of vitamin K at birth. Dietary intake of phylloquinone (PK) differs dramatically by infant feeding practice, but the contribution of microbially produced vitamin K (menaquinones) to infant vitamin K status is not well understood. Objectives: The objective of this study was to investigate determinants of infant fecal vitamin K profiles in mother-infant dyads at 6 wk postpartum. Methods: Fecal and breast milk samples were collected from a subsample of breastfeeding ( Results: Breast milk contained 1.3 ± 0.2 ng/mL PK, and formula was reported to contain 52 ng/mL PK. Fecal PK was 38-times higher ( Conclusions: Feeding practice and delivery mode influence bacterial vitamin K production in the infant gut. High concentrations of unmetabolized PK in feces of formula-fed infants suggests formula PK content exceeds the absorptive capacity of the infant gut.

Indexed as

infant gut microbiotainfant nutritionmenaquinonephylloquinonevitamin K

Identifiers

PMID35295713
PMCPMC8921654
OpenAlexW4210359525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.