Evidence map›Paper›PMID 35295656›Full record

ArticleSchizophrenia bulletin open2022

Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial.

Vinod H Srihari, Maria Ferrara, Fangyong Li, Emily Kline, Sinan Gülöksüz, Jessica M Pollard, John D Cahill, Walter S Mathis, Laura Yoviene Sykes, Barbara C Walsh and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Schizophrenia bulletin open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  4. Clinical outcomes in first-episode psychoses: does age at admission matter?European archives of psychiatry and clinical neuroscience · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Vinod H SrihariProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-1556-2332
Maria FerraraProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2143-1101
Fangyong LiYale Center for Analytical Sciences (YCAS), Yale School of Public Health, New Haven, CT, USA.
Emily KlineDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
Sinan GülöksüzProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Jessica M PollardProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
John D CahillProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Walter S MathisProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Laura Yoviene SykesProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-8863-6921
Barbara C WalshProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Glen McDermottRed Rock Branding, New Haven, CT, USA.
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ralitza GueorguievaProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0944-5973
Scott W WoodsProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Cenk TekProgram for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
STEP-ED:Reducing Duration of Untreated Psychosis and its Impact in the U.S.R01MH103831 · NIMH · YALE UNIVERSITY · PI SRIHARI, VINOD H. · 2013 to 2017
$3.9M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH103831
6 · The paper itself

Abstract

Objective: Duration of Untreated Psychosis (DUP) remains unacceptably long and limits effectiveness of care. To determine whether an early detection campaign ("Mindmap") can reduce DUP in a US community setting. Methods: In this nonrandomized controlled trial, Mindmap targeted the catchment of one specialty first-episode service or FES (STEP, Greater New Haven) from 2015 to 2019, while usual detection efforts continued at a control FES (PREP, Greater Boston). Mindmap targeted diverse sources of delay through mass & social media messaging, professional outreach & detailing, and rapid enrollment of referrals. Both FES recruited 16-35 years old with psychosis onset ≤3 years. Outcome measures included Results: 171 subjects were recruited at STEP and 75 at PREP. Mindmap was associated with an increase in the number of referrals and in efficiency of engagement at STEP. Pre-campaign DUP (2014-2015) was equivalent, while Mindmap was associated with DUP reductions at STEP but not PREP. Conclusions: This is the first controlled demonstration of community DUP reduction in the US, and can inform future early detection efforts across diverse settings.

Indexed as

coordinated specialty care (CSC)early detection (ED)early intervention services (EIS)first-episode psychosis (FEP)first-episode services (FES)pathways to carepopulation healthschizophrenia

Identifiers

PMID35295656
PMCPMC8919192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.