Evidence map›Paper›PMID 35295598›Full record

ArticleFrontiers in medicine2022

Inpatient Administration of Alpha-1-Adrenergic Receptor Blocking Agents Reduces Mortality in Male COVID-19 Patients.

Shilong Li, Tomi Jun, Jonathan Tyler, Emilio Schadt, Yu-Han Kao, Zichen Wang, Maximilian F Konig, Chetan Bettegowda, Joshua T Vogelstein, Nickolas Papadopoulos and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Structural basis of αNature communications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Shilong LiSema4, Stamford, CT, United States.
Tomi JunSema4, Stamford, CT, United States.
Jonathan TylerSema4, Stamford, CT, United States.
Emilio SchadtSema4, Stamford, CT, United States.
Yu-Han KaoSema4, Stamford, CT, United States.
Zichen WangSema4, Stamford, CT, United States.
Maximilian F KonigLustgarten Laboratory, Ludwig Center, The Howard Hughes Medical Institute, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, United States.
Chetan BettegowdaLustgarten Laboratory, Ludwig Center, The Howard Hughes Medical Institute, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, United States.
Joshua T VogelsteinDepartment of Biomedical Engineering, Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD, United States.
Nickolas PapadopoulosLustgarten Laboratory, Ludwig Center, The Howard Hughes Medical Institute, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD, United States.
Ramon E ParsonsDivision of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Rong ChenSema4, Stamford, CT, United States.
Eric E SchadtSema4, Stamford, CT, United States.
Li LiSema4, Stamford, CT, United States.
William K OhSema4, Stamford, CT, United States.
Sema4 (United States) · USIcahn School of Medicine at Mount Sinai · USHoward Hughes Medical Institute · USJohns Hopkins University · US

Funding

COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NIH HHS S10 OD026880NIH HHS S10 OD030463
6 · The paper itself

Abstract

Apha-1-adrenergic receptor antagonists (α

Indexed as

alpha-1-adrenergic receptor antagonistcoronavirus diseaseCOVID-19electronic medical recordinfectious diseasemultivariate logistic analysisoff-label drug usereal-world evidence

Identifiers

PMID35295598
PMCPMC8919772
OpenAlexW4214564948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.