ReviewFrontiers in physiology2022
The Molecular Mechanism of Aerobic Exercise Improving Vascular Remodeling in Hypertension.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Adjuvant music therapy for patients with hypertension: a meta-analysis and systematic review.BMC complementary medicine and therapies · 2023Pooled it
- 4D force patterning enables spatial control of angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of Concurrent Training on Resting and Progressive Exercise Metabolism in Breast Cancer Survivors with Metabolic Syndrome Risk Factors.Nutrients · 2026Article
- Concurrent high-intensity interval plus resistance training improves vascular health in breast cancer survivors with high chemotherapy exposure.Biological research · 2026Article
- Hemodynamics and matrix stiffness shape the pathogenicity of SPP1Frontiers in immunology · 2026Review
- Associations of Cardiocerebrovascular Risks and Exercise according to Menopausal Status in Women with Type 2 Diabetes Mellitus: A Nationwide Cohort Study.Diabetes & metabolism journal · 2026Article
- Dietary Index for Gut Microbiota and Leisure Time Physical Activity: The Potential Combined Protective Impact on Hypertension Risk.Food science & nutrition · 2025Article
- Neurophysiological mechanisms underlying cardiovascular adaptations to exercise: A narrative review.Physiological reports · 2025Review
- Molecular Mechanisms of Vascular Tone in Exercising Pediatric Populations: A Comprehensive Overview on Endothelial, Antioxidative, Metabolic and Lipoprotein Signaling Molecules.International journal of molecular sciences · 2025Review
- Prediction of Cardiac Remodeling and/or Myocardial Fibrosis Based on Hemodynamic Parameters of Vena Cava in Athletes.Current medical imaging · 2025Article
- Molecular crosstalk in perivascular adipose tissue: mechanisms of inflammation, metabolic dysregulation, and therapeutic opportunities in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
- The MuCAYACJC open · 2024Article
- Exploring the Molecular Adaptations, Benefits, and Future Direction of Exercise Training: Updated Insights into Cardiovascular Health.Journal of functional morphology and kinesiology · 2024Review
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
- Association of skeletal muscle mass and risk of hypertension in Korean adults: secondary analysis of data from the community-based prospective cohort study.Frontiers in nutrition · 2023Article
- Physical Activity and Hypertension.Reviews in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment and prevention of hypertension has been a worldwide medical challenge. The key pathological hallmark of hypertension is altered arterial vascular structure and function, i.e., increased peripheral vascular resistance due to vascular remodeling. The aim of this review is to elucidate the molecular mechanisms of vascular remodeling in hypertension and the protective mechanisms of aerobic exercise against vascular remodeling during the pathological process of hypertension. The main focus is on the mechanisms of oxidative stress and inflammation in the pathological condition of hypertension and vascular phenotypic transformation induced by the trilaminar structure of vascular endothelial cells, smooth muscle cells and extracellular matrix, and the peripheral adipose layer of the vasculature. To further explore the possible mechanisms by which aerobic exercise ameliorates vascular remodeling in the pathological process of hypertension through anti-proliferative, anti-inflammatory, antioxidant and thus inhibiting vascular phenotypic transformation. It provides a new perspective to reveal the intervention targets of vascular remodeling for the prevention and treatment of hypertension and its complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.