ArticlePeerJ2022
The Significance of the preoperative lactate dehydrogenase/albumin Ratio in the Prognosis of Colon Cancer: a retrospective study.
Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of controlling nutritional status score (CONUT) in patients with colorectal cancer: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Prognostic significance of the pretreatment controlling nutritional status score in colorectal cancer patients: an updated meta-analysis with 24 cohort studies.Frontiers in nutrition · 2025Pooled it
- Prognostic value of the preoperative lactate dehydrogenase-to-albumin ratio in patients with gastrointestinal cancer.Oncology letters · 2026Article
- Improved 28-day mortality prediction by combining Lactate Dehydrogenase-to-Albumin Ratio(LAR) to lactate-enhanced Sequential Organ Failure Assessment (SOFA) score in patients with sepsis: a derivation and validation study.BMC infectious diseases · 2026Article
- Lactate dehydrogenase-to-albumin ratio and adverse outcomes in patients with HFrEF and HFmrEF.Frontiers in cardiovascular medicine · 2026Article
- Review
- Development of the G-Risk scoring system utilizing inflammatory and tumor biomarkers to improve prognostic accuracy in gastric cancer patients without lymphovascular invasion.European journal of medical research · 2025Article
- Can pretreatment lactate dehydrogenase to albumin ratio predict pathological complete response after neoadjuvant chemotherapy in breast cancer patients?Journal of medical biochemistry · 2025Article
- Energy Metabolism Profiling of Human Colorectal Tumours.Journal of cellular and molecular medicine · 2025Article
- The predictive value of the LDH-albumin ratio on poor clinical course and mortality in COVID-19 patients: A single-center study.Medicine · 2025Observational
- Prognostic value of the lactate dehydrogenase to albumin ratio in advanced non-small cell lung cancer patients treated with the first-line PD-1 checkpoint inhibitors combined with chemotherapy.Frontiers in immunology · 2025Article
- Prognostic value of the lactate dehydrogenase to albumin ratio in cancer patients.Frontiers in nutrition · 2025Article
- Article
- Predictive and Prognostic Value of Inflammatory and Nutritional Indexes in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy.Medicina (Kaunas, Lithuania) · 2024Article
- Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study.Clinical and experimental nephrology · 2024Article
- Effect of Preoperative Serum Lactate Dehydrogenase-to-Albumin Ratio on the Survival of Oral Cancer: A Retrospective Study.Journal of inflammation research · 2024Article
- Article
- Biomarkers of lymph node metastasis in esophageal cancer.Frontiers in immunology · 2024Review
- Prognostic Significance of Preoperative Lactate Dehydrogenase to Albumin Ratio in Breast Cancer: A Retrospective Study.International journal of general medicine · 2023Article
- Laparoscopy and laparotomy for patients with transverse colon cancer: comparative analysis of short-term surgical outcomes.American journal of translational research · 2023Article
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Authors and funding
4 authors.
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Abstract
Background: We explored the relationship between the platelet-lymphocyte ratio (PLR), the prognostic nutritional index (PNI), the lactate dehydrogenase-albumin ratio (LDH/albumin ratio; LAR), the controlling nutritional status (CONUT) score, and the long-term survival of colon cancer patients. Methods: We conducted a retrospective analysis of the clinical data and follow-up materials of 126 patients with colon cancer who underwent surgical treatment in the Department of Gastrointestinal Surgery of Jiangnan University Affiliated Hospital from June 2012 to December 2015. The receiver operating characteristic curve (ROC) was used to distinguish the high ratio group from the low ratio group. The Kaplan Meier method was used to draw the survival curve in our survival analysis. The log rank test was used for the univariate analysis and the Cox multivariate regression analysis was used to analyze the correlation between preoperative PLR, PNI, LAR, conut scores, and overall survival (OS) and progression free survival (PFS) of patients with colon cancer. Results: The median follow-up time was 72 months. The OS rates at 3 and 5 years were 83.3% and 78.5%, respectively. The PFS rates at 3 and 5 years were 79.3% and 77.6%, respectively. The 3-year and 5-year OS rates in the low LAR group (≤4.91) were 90.9% and 87.1%, respectively, and were 56.0% and 44.0% in the high LAR group (>4.91) respectively. Univariate and multivariate analyses showed that the LAR value was correlated with OS and PFS ( Conclusion: A high preoperative LAR is an independent predictor of the prognosis of colon cancer patients.
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