Evidence map›Paper›PMID 35295450›Full record

ArticleFrontiers in pain research (Lausanne, Switzerland)2021

Sex-Specific Abnormalities and Treatment-Related Plasticity of Subgenual Anterior Cingulate Cortex Functional Connectivity in Chronic Pain.

Natalie R Osborne, Dimitri J Anastakis, Junseok Andrew Kim, Rima El-Sayed, Joshua C Cheng, Anton Rogachov, Kasey S Hemington, Rachael L Bosma, Camille Fauchon, Karen D Davis

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pain research (Lausanne, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Natalie R OsborneKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Dimitri J AnastakisKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Junseok Andrew KimKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Rima El-SayedKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Joshua C ChengKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Anton RogachovKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Kasey S HemingtonKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Rachael L BosmaKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Camille FauchonKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Karen D DavisKrembil Research Institute, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Krembil Research InstituteKrembil Foundation · CAUniversity Health Network · CAUniversity of Toronto · CAToronto Western Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The subgenual anterior cingulate cortex (sgACC) is a key node of the descending antinociceptive system with sex differences in its functional connectivity (FC). We previously reported that, in a male-prevalent chronic pain condition, sgACC FC is abnormal in women but not in men. This raises the possibility that, within a sex, sgACC FC may be either protective or represent a vulnerability to develop a sex-dominant chronic pain condition. The aim of this study was to characterize sgACC FC in a female-dominant chronic pain condition, carpal tunnel syndrome (CTS), to investigate whether sgACC abnormalities are a common feature in women with chronic pain or unique to individuals with pain conditions that are more prevalent in the opposite sex. We used fMRI to determine the resting state FC of the sgACC in healthy controls (HCs,

Indexed as

carpel tunnel syndromefMRIfunctional connectivtyneuropathic painpre-frontal cortexsex differencessubgenual anterior cingulate cortextreatment

Identifiers

PMID35295450
PMCPMC8915549
OpenAlexW3178826209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.