Evidence map›Paper›PMID 35295415›Full record

ArticleFrontiers in pain research (Lausanne, Switzerland)2021

Genomic Effects Associated With Response to Placebo Treatment in a Randomized Trial of Irritable Bowel Syndrome.

Rui-Sheng Wang, Anthony J Lembo, Ted J Kaptchuk, Vivian Cheng, Judy Nee, Johanna Iturrino, Meenakshi Rao, Joseph Loscalzo, Jocelyn A Silvester, Kathryn T Hall

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pain research (Lausanne, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rui-Sheng WangDepartment of Medicine, Brigham Women's Hospital, Boston, MA, United States.
Anthony J LemboDepartment of Medicine, Harvard Medical School, Boston, MA, United States.
Ted J KaptchukProgram in Placebo Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Vivian ChengDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Judy NeeDepartment of Medicine, Harvard Medical School, Boston, MA, United States.
Johanna IturrinoDepartment of Medicine, Harvard Medical School, Boston, MA, United States.
Meenakshi RaoDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, United States.
Joseph LoscalzoDepartment of Medicine, Brigham Women's Hospital, Boston, MA, United States.
Jocelyn A SilvesterDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Kathryn T HallDepartment of Medicine, Brigham Women's Hospital, Boston, MA, United States.
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8M
TRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI MALISZEWSKI, LAURA ELIZABETH · 2014 to 2018
$10.8M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
Efficacy of Open-Label Placebo, Double-Blind Placebo, and Peppermint Oil in IBSR01AT008573 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAPTCHUK, TED, LEMBO, ANTHONY J · 2015 to 2019
$4.3M
Mechanisms and Markers of Small Intestinal Epithelial Injury and Villous AtrophyK23DK119584 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SILVESTER, JOCELYN ANNE · 2019 to 2023
$971k
Epidemiological, pharmacogenomic and clinical impact of catechol-O-methyltransferase on cardiovascular diseaseK01HL130625 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HALL, KATHRYN TAYO · 2016 to 2021
$921k
Enteric Glia, Sexual Dimorphism and GI MotilityK08DK110532 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAO, MEENAKSHI · 2016 to 2021
$862k
NCCIH NIH HHS R01 AT008573NHGRI NIH HHS U01 HG007690NHLBI NIH HHS K01 HL130625NHLBI NIH HHS U54 HL119145NIDDK NIH HHS K08 DK110532NIDDK NIH HHS K23 DK119584NIGMS NIH HHS P50 GM107618
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

catechol-O-methyltransferase (COMT)gene expressionirritable bowel syndrome (IBS)placebosrandomized control trial (RCT)

Identifiers

PMID35295415
PMCPMC8915627
OpenAlexW4206709674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.