ArticleFrontiers in pediatrics2021
Factors Associated With Neural Tube Defects Among Newborns Delivered at Debre Berhan Specialized Hospital, North Eastern Ethiopia, 2021. Case-Control Study.
Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- MaternalGenes · 2026Article
- The burden of neural tube defects in Southern Ethiopia: trends, hotspots, and public health implications.PeerJ · 2026Article
- Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries.BMC pregnancy and childbirth · 2025Article
- Perinatal Outcomes in Patients With Neural Tube Defects in a Middle-Income Setting.Birth defects research · 2025Article
- A computational dynamic systems model forCurrent research in toxicology · 2025Article
- Neural tube defect among newborns in public hospitals of Tigray region, northern Ethiopia: A cross-sectional study.PloS one · 2025Article
- Determinants of neural tube defects among newborns in public referral hospitals in Eastern Ethiopia.BMC nutrition · 2023Article
- Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis.International journal of pediatrics · 2023Review
- Timing of perinatal death; causes, circumstances, and regional variations among reviewed deaths in Ethiopia.PloS one · 2023Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neural tube defects are severe congenital malformations secondary to an abnormal closure of the neural tube between third and fourth weeks of gestational ages. Neural tube defects affect birth outcomes worldwide, with an occurrence of 18.6 per 10,000 live births. In addition, neural tube defects are associated with considerable mortality, morbidity, disability, and socio-economical cost. Objective: To identify factors associated with neural tube defects among newborns delivered at Debre Berhan Comprehensive Specialized Hospital, 2021. Methods: Facility-based case-control study design was conducted among 381 (127 cases and 254 controls) newborns delivered from June 2019 to June 2021 at Debre Berhan Specialized Hospital. Consecutive and systematic random sampling techniques were used to select cases and controls, respectively. Data were collected using semi-structured checklists. Finally, data were entered using Epidata version 4.2.1 and analyzed using SPSS version 25. In the bivariable logistic regression model, factors with a Result: In this study, 381 newborns (127 cases and 254 controls) participated with a response rate of 100%. In the logistic regression model, mothers who took medication during pregnancy [AOR 1.83 (95% CI 1.08-3.08)], mothers who did not take a balanced diet during pregnancy [AOR 13.46 (95% CI 7.83-23.13)], and mothers who did not take folic acid before and during the first trimester of pregnancy [AOR 1.71 (95% CI 1.01-2.94)] were significantly associated with neural tube defect. Conclusion and Recommendation: Mothers who took medication during pregnancy, mothers who did not take balanced diets during pregnancy, and mothers who did not take folic acid during pregnancy were the significant factors of neural tube defects. Health care professionals should focus on maternal safe drug prescription, maternal folate intake, and a balanced diet before and during pregnancy.
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