Evidence map›Paper›PMID 35295231›Full record

ArticleERJ open research2022

The impact of personal and outdoor temperature exposure during cold and warm seasons on lung function and respiratory symptoms in COPD.

Charlotte Scheerens, Lina Nurhussien, Amro Aglan, Andrew J Synn, Brent A Coull, Petros Koutrakis, Mary B Rice

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  10. What's new in the 2025 GOLD report.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Article
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  18. A cross-sectional survey on the effects of ambient temperature and humidity on health outcomes in individuals with chronic respiratory disease.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Charlotte ScheerensDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Lina NurhussienDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Amro AglanDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Andrew J SynnDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0003-3215-4808
Brent A CoullDept of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Petros KoutrakisDept of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Mary B RiceDivision of Pulmonary, Sleep and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0003-2538-391X
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The American Lung Association (ALA) Lung Health CohortU01HL146408 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARNETHON, MERCEDES RENEE, KALHAN, RAVI · 2019 to 2024
$25.2M
A Randomized Controlled Trial of Home Air Purification for Eosinophilic COPDR01ES031252 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI RICE, MARY B · 2020 to 2025
$3.8M
Air Pollution and the Lung in Health and COPD: Obstructive, Restrictive and Vascular PathwaysK23ES026204 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICE, MARY B · 2016 to 2020
$883k
Cardiopulmonary Manifestations and Translational Potential of a Novel Radiographic Biomarker of Pulmonary Vascular MorphologyF32HL143819 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SYNN, ANDREW · 2019 to 2021
$266k
NHLBI NIH HHS F32 HL143819NHLBI NIH HHS U01 HL146408NIEHS NIH HHS K23 ES026204NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES031252
6 · The paper itself

Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) patients often report aggravated symptoms due to heat and cold, but few studies have formally evaluated this. Methodology: We followed 30 Boston-based former smokers with COPD for four non-consecutive 30-day periods over 12 months. Personal and outdoor temperature exposure were measured using portable and Boston-area outdoor stationary monitors. Participants recorded daily morning lung function measurements as well as any worsening breathing (breathlessness, chest tightness, wheeze) and bronchitis symptoms (cough, sputum colour and amount) compared to baseline. Using linear and generalised linear mixed-effects models, we assessed associations between personal and outdoor temperature exposure (1-3-day moving averages) and lung function and symptoms, adjusting for humidity, smoking pack-years and demographics. We also stratified by warm and cold season. Results: Participants were on average 71.1±8.4 years old, with 54.4±30.7 pack-years of smoking. Each 5°C increase in personal temperature exposure was associated with 1.85 (95% CI 0.99-3.48) higher odds of worsening breathing symptoms. In the warm season, each 5°C increase in personal and outdoor temperature exposure was associated with 3.20 (95% CI 1.05-9.72) and 2.22 (95% CI 1.41-3.48) higher odds of worsening breathing symptoms, respectively. Each 5°C decrease in outdoor temperature was associated with 1.25 (95% CI 1.04-1.51) higher odds of worsening bronchitis symptoms. There were no associations between temperature and lung function. Conclusions: Our findings suggest that higher temperature, including outdoor exposure during the warm season and personal temperature exposure year-round, may worsen dyspnoea, while colder outdoor temperature may trigger cough and phlegm symptoms among COPD patients.

Identifiers

PMID35295231
PMCPMC8918937
OpenAlexW4210269942

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.