Evidence map›Paper›PMID 35295181›Full record

ArticleNeurology. Genetics2022

ALS in Finland: Major Genetic Variants and Clinical Characteristics of Patients With and Without the

Hannu Laaksovirta, Jyrki Launes, Lilja Jansson, Bryan J Traynor, Karri Kaivola, Pentti J Tienari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  13. Frontiers in genetics · 2023
    Article
  14. Response to the letter by de Boer et al. (2022).Acta neuropathologica communications · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hannu LaaksovirtaDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.ORCID https://orcid.org/0000-0002-2380-8999
Jyrki LaunesDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.ORCID https://orcid.org/0000-0002-3477-398X
Lilja JanssonDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.
Bryan J TraynorDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.ORCID https://orcid.org/0000-0002-3010-8851
Karri KaivolaDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.ORCID https://orcid.org/0000-0003-1218-4014
Pentti J TienariDepartment of Neurology (H.L., K.K., P.J.T.), Helsinki University Hospital; Translational Immunology (H.L., L.J., K.K., P.J.T.), Research Programs Unit, University of Helsinki; Department of Psychology and Logopedics (J.L.), University of Helsinki, Finland; and Neuromuscular Diseases Research Section (B.J.T.), Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.ORCID https://orcid.org/0000-0001-5686-2900
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: To analyze the frequencies of major genetic variants and the clinical features in Finnish patients with amyotrophic lateral sclerosis (ALS) with or without the Methods: A cohort of patients with motor neuron disease was recruited between 1993 and 2020 at the Helsinki University Hospital and 2 second-degree outpatient clinics in Helsinki. Finnish ancestry patients with ALS fulfilled the diagnosis according to the revised El Escorial criteria and the Awaji-criteria. Two categories of familial ALS (FALS) were used. A patient was defined FALS-A if at least 1 first- or second-degree family member had ALS, and FALS-NP, if family members had additional neurologic or psychiatric endophenotypes. Results: Of the 815 patients, 25% had FALS-A and 45% FALS-NP. Discussion: These results provide further evidence for the short survival of

Identifiers

PMID35295181
PMCPMC8922337
OpenAlexW4220803629

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.