Evidence map›Paper›PMID 35295152›Full record

ReviewFrontiers in toxicology2021

Radiolabeling of Nanomaterials: Advantages and Challenges.

Wanqin Dai, Junzhe Zhang, Yun Wang, Chunlei Jiao, Zhuda Song, Yuhui Ma, Yayun Ding, Zhiyong Zhang, Xiao He

Abstract readReview
In one paragraph

Review in Frontiers in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wanqin DaiCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Junzhe ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yun WangCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Chunlei JiaoCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Zhuda SongCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Yuhui MaCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Yayun DingCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Zhiyong ZhangCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.
Xiao HeCAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the "last-step" labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.

Indexed as

derivatization strategyincorporation strategyin vivo stabilitynanomaterialsradiolabelingradiotracer technique

Identifiers

PMID35295152
PMCPMC8915866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.