ArticleProgress in biomaterials2022
Graphene-tethered 5-fluorouracil-loaded ZnO nanocomposites for pH-responsive enhanced efficacy in drug delivery on MCF-7 cells.
Article in Progress in biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Silver nitrate functionalized rice husk-derived graphene oxide as a nanocarrier for pH-responsive drug delivery.Discover nano · 2025Article
- Biodegradable graphene nanocomposites as functional biomaterials: a review of their role in controlled drug delivery and tissue engineering.RSC advances · 2025Review
- ZnO-Graphene Oxide Nanocomposite for Paclitaxel Delivery and Enhanced Toxicity in Breast Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: AnBioMed research international · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene-tethered ZnO nanocomposites with rod shapes and oval-shaped 5-fluorouracil-loaded graphene-supported ZnO nanohybrids were synthesized using one pot wet chemical bottom up coprecipitation method. The presence of hexagonal nanophase of ZnO lattice with surface-tethered graphene sheets were confirmed using XRD pattern and supportive UV-Vis and FTIR spectrum. XRD data of these nanocomposites were matched with TEM images which proved the hexagonal ZnO core maintained even after surface tailoring with graphene and drug loading. These porous nanocomposites were loaded with anticancer drug 5-fluorouracil for enhancement in anticancer activity on breast cancer MCF-7 cells. The optical, morphological and phase physicochemical characterizations of the nanohybrids were performed using techniques as UV-Vis, FTIR, XRD spectrometry, and TEM microscopic analysis. The nanocomposites did not only exhibit biocompatibility but also pH responsive in vitro delivery applied for anticancer therapy on the basis of spectrometric MTT assay following sustained drug release with zero-order Peppas release kinetics. These nanocomposites exhibited higher anticancer activity on MCF-7 cells than free drug after in vitro MTT assay. On the basis of these demonstrations, these newer nanocomposites find future biomedical applications in pH-responsive drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.