ArticleThe Journal of clinical endocrinology and metabolism2022
Proteomic Profiles of Body Mass Index and Waist-to-Hip Ratio and Their Role in Incidence of Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Prevalence of Depression and Associated Factors Among Adult Diabetic Men on Follow-Up at Goba and Robe Hospitals: Institution-Based Cross-Sectional Study.Health science reports · 2026Article
- Level of physical activity and its predictors among adult diabetic men who were on follow-up at health facilities in Bale Zone, Southeast Ethiopia: institution-based cross-sectional study.BMC research notes · 2026Article
- Proteomic Signature of BMI and Risk of Type 2 Diabetes.Diabetes · 2025Article
- Proteomic changes upon treatment with semaglutide in individuals with obesity.Nature medicine · 2025Article
- Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels.Communications biology · 2024Article
- Comparison of obesity indicators for predicting cardiovascular risk factors and multimorbidity among the Chinese population based on ROC analysis.Scientific reports · 2024Article
- The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population.BMC endocrine disorders · 2024Article
- Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study.Scientific reports · 2024Article
- Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression.Nature communications · 2024Article
- Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.BMC medicine · 2023Article
- Magnitude of erectile dysfunction and associated factors among adult diabetic men on follow-up at Goba and Robe hospitals, Bale Zone, South East Ethiopia: hospital-based cross-sectional study.BMC endocrine disorders · 2023Article
- Healthy lifestyle linked to innate immunity and lipoprotein metabolism: a cross-sectional comparison using untargeted proteomics.Scientific reports · 2023Article
- Conventional and genetic associations of adiposity with 1463 proteins in relatively lean Chinese adults.European journal of epidemiology · 2023Article
- Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.medRxiv : the preprint server for health sciences · 2023Article
- The Sexual Dimorphism of Human Adipose Depots.Biomedicines · 2022Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
contextIt is unclear to what extent the plasma proteome of abdominal fat distribution differs from that of body mass index, and whether the differences have clinical implications.
objectiveTo evaluate the difference between the plasma proteomic profiles of body mass index (BMI) and waist-to-hip ratio (WHR), and then examine the identified BMI- or WHR-specific proteins in relation to incidence of diabetes.
methodsData were obtained from the Malmö Diet and Cancer-Cardiovascular Cohort study in the general community. Participants (n = 4203) with no previous diabetes (aged 57.2 ± 6.0 years, 37.8% men) were included. Plasma proteins (n = 136) were measured by the Proseek proximity extension method. BMI- and WHR-specific proteins were identified at baseline using a 2-step iterative resampling approach to optimize internal replicability followed by β coefficient comparisons. The identified proteins were considered internally replicated and were then studied in relation to incident diabetes by Cox proportional hazards regression analysis. The main outcome measure was incident diabetes over a mean follow-up of 20.3 ± 5.9 years.
resultsAfter excluding 21 overlapping proteins and proteins that did not show significantly different associations with BMI vs WHR, 10 internally replicated proteins were found to be specific to BMI, and 22 were found to be specific to WHR (false discovery rate-adjusted P < .05). Of the WHR-specific proteins, 18 remained associated with diabetes risk after multivariate adjustments, whereas none of the BMI-specific proteins showed associations with diabetes risk.
conclusionAbdominal fat distribution was associated with some unique characteristics of the plasma proteome that potentially could be related to its additional risk of diabetes beyond general obesity.
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