ArticleNeuron2022
Brain-wide electrical dynamics encode individual appetitive social behavior.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 41 citations in OpenAlex.
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- Generative Principal Component Regression via Variational Inference.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2026Article
- Mapping memory at scale: systems-level insights with translational and transdiagnostic relevance to fear-related disorders.Frontiers in behavioral neuroscience · 2026Review
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- Sex-specific regulation of microglial MyD88 in HMGB1-Induced anxiety phenotype in mice.Neurobiology of stress · 2025Article
- Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions.Translational psychiatry · 2025Article
- The NERVE-ML (neural engineering reproducibility and validity essentials for machine learning) checklist: ensuring machine learning advances neural engineeringJournal of neural engineering · 2025Review
- Electrophysiological recording during touchscreen-based behavioral assays in rodents: A platform for improving early-stage neuroscience drug discovery.Journal of neurochemistry · 2025Review
- Biomarker discovery using machine learning in the psychosis spectrum.Biomarkers in neuropsychiatry · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Microglial MyD88-dependent pathways are regulated in a sex-specific manner in the context of HMGB1-induced anxiety.bioRxiv : the preprint server for biology · 2024Article
- A widespread electrical brain network encodes anxiety in health and depressive states.bioRxiv : the preprint server for biology · 2024Article
- Electome network factors: Capturing emotional brain networks related to health and disease.Cell reports methods · 2024Review
- Synchronized LFP rhythmicity in the social brain reflects the context of social encounters.Communications biology · 2024Article
- Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation.Frontiers in psychiatry · 2024Article
- Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes.National science review · 2024Article
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19 authors at 4 institutions in 1 country.
Funding
Abstract
The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in a social preference assay. We then use machine learning to discover a network that encodes the extent to which individual mice engage another mouse. This network is organized by theta oscillations leading from prelimbic cortex and amygdala that converge on the ventral tegmental area. Network activity is synchronized with cellular firing, and frequency-specific activation of a circuit within this network increases social behavior. Finally, the network generalizes, on a mouse-by-mouse basis, to encode individual differences in social behavior in healthy animals but fails to encode individual behavior in a 'high confidence' genetic model of autism. Thus, our findings reveal the architecture whereby the brain integrates distributed activity across timescales to encode an appetitive brain state underlying individual differences in social behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.