ArticleCurrent biology : CB2022
Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
- Tomato plants control leaf sodium levels to limit damage by Spodoptera littoralis larvae.The New phytologist · 2026Article
- Modulation of attractive salt taste iniScience · 2026Article
- Insulin and leucokinin pathways coordinate adaptive salt appetite inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- Stress-induced preference for antioxidants byProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner.Molecules and cells · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.PLoS neglected tropical diseases · 2025Article
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Article
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
- Single-Sensillum Taste Recordings in Mosquitoes.Cold Spring Harbor protocols · 2024Article
- Molecular and cellular basis of sodium sensing iniScience · 2024Article
- Avoiding alkaline taste through ionotropic receptors.iScience · 2024Article
- Postprandial sodium sensing by enteric neurons in Drosophila.Nature metabolism · 2024Article
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Abstract
Salt taste is one of the most ancient of all sensory modalities. However, the molecular basis of salt taste remains unclear in invertebrates. Here, we show that the response to low, appetitive salt concentrations in Drosophila depends on Ir56b, an atypical member of the ionotropic receptor (Ir) family. Ir56b acts in concert with two coreceptors, Ir25a and Ir76b. Mutation of Ir56b virtually eliminates an appetitive behavioral response to salt. Ir56b is expressed in neurons that also sense sugars via members of the Gr (gustatory receptor) family. Misexpression of Ir56b in bitter-sensing neurons confers physiological responses to appetitive doses of salt. Ir56b is unique among tuning Irs in containing virtually no N-terminal region, a feature that is evolutionarily conserved. Moreover, Ir56b is a "pseudo-pseudogene": its coding sequence contains a premature stop codon that can be replaced with a sense codon without loss of function. This stop codon is conserved among many Drosophila species but is absent in a number of species associated with cactus in arid regions. Thus, Ir56b serves the evolutionarily ancient function of salt detection in neurons that underlie both salt and sweet taste modalities.
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