SynthesisDigestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society2022
Oral sulfate solution benefits polyp and adenoma detection during colonoscopy: Meta-analysis of randomized controlled trials.
Synthesis in Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Oral sulfate solution versus polyethylene glycol for bowel preparation before colonoscopy, meta-analysis and trial sequential analysis of randomized clinical trials.Techniques in coloproctology · 2024Pooled it
- A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy.BMC gastroenterology · 2025Trial
- Low-residue diet with oral nutritional supplements prior to colonoscopy improves the quality of bowel preparation: an endoscopist-blinded, randomized controlled trial.BMC gastroenterology · 2025Trial
- A prospective, single-blinded, non-inferiority, randomized controlled study comparing the effectiveness and safety of oral lactulose combined with carbohydrate-containing clear liquids versus 3-L polyethylene glycol electrolyte for colonoscopy bowel preparation.European journal of medical research · 2025Trial
- Oral sulfate-based versus low-volume polyethylene glycol-ascorbate regimens for colonoscopy preparation in the geriatric population: a systematic review and meta-analysis of randomized controlled trials.Clinical endoscopy · 2026Article
- Bowel Bubble Formation with Oral Sulfate Solution for Colonoscopy Bowel Preparation Using Same-Day and Split-Day Regimens: The B-BOSS Study.Diagnostics (Basel, Switzerland) · 2026Article
- Updated bowel preparation regimens for colonoscopy: benefits and drawbacks.Clinical endoscopy · 2026Review
- Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities.World journal of gastroenterology · 2026Review
- Retrospective Analysis of Bowel Bubbles During Colonoscopy Following Bowel Preparation with Oral Sulfate Solution or 2 L Polyethylene Glycol-Electrolyte Solution with Ascorbic Acid.Digestive diseases and sciences · 2025Article
- Bowel Cleansing Effectiveness of Sulfate-Based Tablet Versus Sulfate-Based Solution for Outpatient Colonoscopy: A Retrospective Noninferiority Study.Digestive diseases and sciences · 2025Article
- Review
- Effectiveness of a Mobile Health Application for Educating Outpatients about Bowel Preparation.Healthcare (Basel, Switzerland) · 2024Article
- The Efficacy of 480 ml Oral Sodium Sulfate for Improving Insufficient Bowel Preparation of Colonoscopy with High-Concentrated Polyethylene Glycol.Gastroenterology research and practice · 2023Article
- Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy.Frontiers in oncology · 2022Article
- Evaluation of parameters influencing the quality of colon preparation with a split-dose regimen of sulfate salts.Annals of gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough oral sulfate solution (OSS) has been revealed to be not only safe and efficacious but also noninferior to polyethylene glycol with ascorbic acid (PEG + ASC), it is unclear whether OSS can ultimately increase the polyp detection rate (PDR) and adenoma detection rate (ADR). We performed this meta-analysis to estimate the effect of OSS on PDR and ADR during colonoscopy.
methodsWe searched PubMed, EMBASE, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) investigating the comparative effect of OSS versus PEG + ASC on the PDR and ADR during colonoscopy. Cecal intubation time (CIT), cecal intubation rate (CIR), and bowel preparation score were also evaluated. Review Manager (RevMan) version 5.3.0 was used to perform statistical analysis.
resultsEight RCTs involving 2059 patients fulfilled the selection criteria. Meta-analysis suggested that OSS significantly increased the PDR (47.34% vs. 40.14%, risk ratio [RR] 1.13, 95% confidence interval [CI] 1.03-1.24, P = 0.01) and ADR (44.60% vs. 38.14%, RR 1.17, 95% CI 1.03-1.33, P = 0.01) during colonoscopy. Subgroup analysis showed that the beneficial effects of OSS on PDR and ADR were consistent among patients with mean age >55 years and with body mass index <25 kg/m
conclusionCompared with polyethylene glycol-based regimens, the OSS bowel preparation regimen significantly increased the PDR and ADR in patients undergoing colonoscopy.
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