ArticleInternational urology and nephrology2022
Validation of an equation for free calcium estimation: accuracy improves after adjustment for phosphate and CO
Article in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Intraoperative Parathyroid Hormone Monitoring During Parathyroidectomy in Severe Secondary Hyperparathyroidism due to Kidney Failure.World journal of surgery · 2026Article
- Use of Data Mining in the Establishment of Reference Intervals for Albumin-Adjusted Calcium.Clinical endocrinology · 2025Article
- Use of Albumin-Adjusted Calcium Measurements in Clinical Practice.JAMA network open · 2025Article
- Long-term effects of hypercalcemia in kidney transplant recipients with persistent hyperparathyroidism.Journal of nephrology · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFree calcium is the gold standard for diagnosis of calcium disorders, although calcium assessment is routinely performed by albumin-adjusted calcium. Our objective was to develop a novel-specific correction equation for free calcium employing serum total calcium and other analytes.
methodsRetrospective single-center cohort study. A new equation for free calcium assessment was formulated from data of hospitalized patients (n = 3481, measurements = 7157) and tested in a validation cohort (n = 3218, measurements = 6911). All measurements were performed simultaneously from the same blood draw.
resultsTotal CO
conclusionsThe novel equation proposed for prediction of free calcium could be useful when free calcium is not available. The conventional formulas misclassify many patients, in particular when phosphate or bicarbonate disturbances are present.
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