Evidence map›Paper›PMID 35294629›Full record

ArticleEJNMMI physics2022

Deep learning for Dixon MRI-based attenuation correction in PET/MRI of head and neck cancer patients.

Anders B Olin, Adam E Hansen, Jacob H Rasmussen, Björn Jakoby, Anne K Berthelsen, Claes N Ladefoged, Andreas Kjær, Barbara M Fischer, Flemming L Andersen

Open access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Anders B OlinDepartment of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. anders.olin@regionh.dk.ORCID http://orcid.org/0000-0002-7768-5664
Adam E HansenDepartment of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Jacob H RasmussenDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Björn JakobySiemens Healthcare GmbH, Erlangen, Germany.
Anne K BerthelsenDepartment of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Claes N LadefogedDepartment of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Andreas KjærDepartment of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Barbara M Fischer *Department of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Flemming L Andersen *Department of Clinical Physiology, Nuclear Medicine and PET & Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
University of Copenhagen · DKUniversity of Surrey · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantitative whole-body PET/MRI relies on accurate patient-specific MRI-based attenuation correction (AC) of PET, which is a non-trivial challenge, especially for the anatomically complex head and neck region. We used a deep learning model developed for dose planning in radiation oncology to derive MRI-based attenuation maps of head and neck cancer patients and evaluated its performance on PET AC.

methodsEleven head and neck cancer patients, referred for radiotherapy, underwent CT followed by PET/MRI with acquisition of Dixon MRI. Both scans were performed in radiotherapy position. PET AC was performed with three different patient-specific attenuation maps derived from: (1) Dixon MRI using a deep learning network (PET

resultsThe average (± standard deviation) PET voxel error was 0.0 ± 11.4% for PET

conclusionThe deep learning network for deriving MRI-based attenuation maps of head and neck cancer patients demonstrated accurate AC and exceeded the performance of the vendor-provided atlas-based method both overall, on a lesion-level, and in vicinity of challenging regions such as bone and air.

Indexed as

Deep learningHead and neck cancerMR-ACPET/MRI

Identifiers

PMID35294629
PMCPMC8927520
OpenAlexW4221131219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.