Evidence map›Paper›PMID 35294598›Full record

ArticleArchives of toxicology2022

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome

Shensheng Zhao, Sebastiaan Wesseling, Ivonne M C M Rietjens, Marije Strikwold

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Physiologically based Kinetic Modeling-Facilitated QuantitativeJournal of agricultural and food chemistry · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shensheng ZhaoDivision of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. shensheng.zhao22@gmail.com.ORCID 0000-0003-4300-6878
Sebastiaan WesselingDivision of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Ivonne M C M RietjensDivision of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Marije StrikwoldVan Hall Larenstein University of Applied Sciences, 8901 BV, Leeuwarden, The Netherlands.
Wageningen University & Research · NLVan Hall Larenstein University of Applied Sciences · NL

Funding

China Scholarship Council 201707720063
6 · The paper itself

Abstract

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HK

Indexed as

ChlorpyrifosAcetylcholinesteraseCytochrome P-450 Enzyme SystemHumansKineticsLiverMicrosomes, LiverModels, BiologicalMonte Carlo MethodToxicokineticsAcetylcholinesteraseChlorpyrifosCytochrome P-450 Enzyme SystemChlorpyrifos (CPF)Inter-individual differencesMonte Carlo (MC) simulationPhysiologically based kinetic (PBK) modelingRed blood cell (RBC) acetylcholinesterase (AChE) inhibition

Identifiers

PMID35294598
PMCPMC9013686
OpenAlexW4220654740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.