ArticleEuropean radiology2022
A functional liver imaging score for preoperative prediction of liver failure after hepatocellular carcinoma resection.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Application of indocyanine green-mediated fluorescence molecular imaging technology in liver tumors resection: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Do hepatic and biliary functional data from gadoxetate-enhanced MRI add value in predicting outcomes in primary sclerosing cholangitis (PSC)?European radiology · 2026Article
- The diagnostic value of MRE in patients with decompensated cirrhosis: comparing it to Gd-EOB-DTPA-enhanced MRI.BMC medical imaging · 2026Article
- Improving surgical treatments for hepatocellular carcinoma.Nature reviews. Gastroenterology & hepatology · 2026Review
- Predictive model development and validation of functional liver imaging score for prognosis of patients with hepatocellular carcinoma after surgical resection: a multicenter study.La Radiologia medica · 2026Article
- Incorporating parenchymal heterogeneity into FLIS to improve MRI-based liver function assessment.Insights into imaging · 2026Article
- Preoperative Systemic Pan-Immune-Inflammation Value Predicts Posthepatectomy Liver Failure After Laparoscopic Resection for Hepatocellular Carcinoma: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Functional liver imaging score derived from hepatobiliary-specific contrast-enhanced MRI: a study on agreement and correlation.Insights into imaging · 2025Article
- Liver Functions in Patients with Chronic Liver Disease and Liver Cirrhosis: Correlation of FLIS and LKER with PALBI Grade and APRI.Current medical imaging · 2025Article
- Liver function estimation using multiphase hepatic CT: diagnostic performance of iodine-uptake and volumetric parameters.European radiology · 2025Article
- Differentiation of dual- and non-dual-phenotype hepatocellular carcinoma based on contrast-enhanced computed tomography and patient characteristics.Quantitative imaging in medicine and surgery · 2025Article
- Application of ultrasound elastography and splenic size in predicting post-hepatectomy liver failure: Unveiling new clinical perspectives.World journal of gastroenterology · 2025Article
- Validation of functional liver imaging scores derived on gadoxetic acid-enhanced MRI in hepatocellular carcinoma patients.Hepatology forum · 2025Article
- Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection.Journal of hepatocellular carcinoma · 2025Article
- Low functional liver imaging score is associated with poor prognosis following hepatectomy for hepatocellular carcinoma.Scientific reports · 2024Article
- Advanced Imaging of Hepatocellular Carcinoma: A Review of Current and Novel Techniques.Journal of gastrointestinal cancer · 2024Review
- Nomogram based on liver stiffness and spleen area with ultrasound for posthepatectomy liver failure: A multicenter study.World journal of gastroenterology · 2024Observational
- Noninvasive diagnosis of liver cirrhosis: qualitative and quantitative imaging biomarkers.Abdominal radiology (New York) · 2024Review
- Hepatobiliary phase imaging in cirrhotic patients using compressed sensing and controlled aliasing in parallel imaging results in higher acceleration.European radiology · 2024Article
- Evaluation and Prediction of Post-Hepatectomy Liver Failure Using Imaging Techniques: Value of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging.Korean journal of radiology · 2024Review
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8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPosthepatectomy liver failure (PHLF) is a challenging complication after resection to treat hepatocellular carcinoma (HCC), and it is associated with high mortality. Preoperative prediction of PHLF may improve patient subsequent and reduce such mortality. This study examined whether a functional liver imaging score (FLIS) based on preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI) could predict PHLF. MATERIALS AND
methodsThe study included 502 patients who underwent preoperative gadoxetic acid-enhanced MRI, followed by HCC resection. Significant preoperative predictors of PHLF were identified using logistic regression analysis. The ability of FLIS to predict PHLF was evaluated using receiver operating characteristic curves, and its predictive power was compared to that of the model for end-stage liver disease (MELD) score, albumin-bilirubin (ALBI) score, and indocyanine green 15-min retention rate (ICG-R15).
resultsIn multivariate analysis, PHLF was independently associated with FLIS (OR 0.452, 95% CI 0.361 to 0.568, p < 0.001) and major resection (OR 1.898, 95% CI 1.057 to 3.408, p = 0.032). FLIS was associated with a higher area under the receiver operating characteristic curve (0.752) than the MELD score (0.557), ALBI score (0.609), or ICG-R15 (0.605) (all p < 0.05). Patients with FLIS ≤ 4 who underwent major resection were at 9.4-fold higher risk of PHLF than patients with lower FLIS who underwent minor resection.
conclusionFLIS is an independent predictor of PHLF, and it may perform better than the MELD score, ALBI score, and ICG-R15 clearance. We propose treating elevated FLIS and major resection as risk factors for PHLF. KEY POINTS: • A functional liver imaging score can independently predict posthepatectomy liver failure in patients with HCC. • The score may predict such failure better than MELD and ALBI scores and ICG-R15. • Patients with scores ≤ 4 who undergo major hepatic resection may be at nearly tenfold higher risk of posthepatectomy liver failure.
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