ArticleAdvances in biochemical engineering/biotechnology2022
Bacillus sp.: A Remarkable Source of Bioactive Lipopeptides.
Article in Advances in biochemical engineering/biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Genomic and transcriptomic analysis of yield enhancement mechanism of lipopeptide iturin W by tryptone supplementation.Microbiology spectrum · 2026Article
- Mycosubtilin Induces G1 Phase Block and Autophagy in Cervical Cancer HeLa Cells.Probiotics and antimicrobial proteins · 2026Article
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- Identification and Genomic Insights into the Biological Control and Growth-Promoting Mechanism ofMicroorganisms · 2025Article
- Bacterial Cyclic Lipopeptides as Triggers of Plant Immunity and Systemic Resistance Against Pathogens.Plants (Basel, Switzerland) · 2025Review
- Biosynthesis and yield improvement strategies of fengycin.Archives of microbiology · 2025Review
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Optimisation of surfactin yield inComputational and structural biotechnology journal · 2024Article
- The structure of lipopeptides impacts their antiviral activity and mode of action against SARS-CoV-2Applied and environmental microbiology · 2024Article
- In Vivo Quantification of Surfactin Nonribosomal Peptide Synthetase Complexes inMicroorganisms · 2024Article
- Strategies for improving fengycin production: a review.Microbial cell factories · 2024Review
- Bacterial Lipopeptides Are Effective against Pear Fire Blight.Microorganisms · 2024Article
- Review
- Strong Opponent of Walnut Anthracnose-Microorganisms · 2023Article
- Article
- LC-MS and Transcriptome Analysis of Lipopeptide Biosynthesis byMolecules (Basel, Switzerland) · 2022Article
- Identification of Lipopeptide Iturin A Produced byFoods (Basel, Switzerland) · 2022Article
- Characterization of subtilosin gene in wild type Bacillus spp. and possible physiological role.Scientific reports · 2022Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surfactin, one of the best lipopeptide surfactants, was first isolated from Bacillus sp. in 1969. Since then, Bacillus sp. has been a remarkable source of bioactive lipopeptides, with a huge natural biodiversity. Lipopeptides from Bacillus sp. are now divided into three main families: surfactin, fengycin, and iturin. The peptide moiety of these lipopeptides is synthesised by huge multi-enzymatic proteins called nonribosomal peptide synthetases, which are responsible for the peptide biodiversity of these lipopeptides. Moreover, the fatty acid chain also encompasses a high diversity with different β-hydroxy or β-amino fatty acid chains of different lengths, isomery, or saturation, which can be incorporated. After describing the mode of synthesis of the different families of lipopeptides produced by Bacillus sp. and their biodiversity, this chapter describes how this lipopeptide biodiversity can be increased using genetic engineering and how the lipopeptides can be overproduced and purified. The high biodiversity of lipopeptides induces a broad range of physicochemical properties, which can be linked to multiple biological activities with many applications in different sectors. The increasing understanding of the mode of biosynthesis of these lipopeptides should lead to the development of novel compounds with increased properties and applications.
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