Evidence map›Paper›PMID 35294550›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2022

Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic.

Karl W Boehme, Joshua L Kennedy, Jessica Snowden, Shana M Owens, Marianne Kouassi, Ryan L Mann, Amairani Paredes, Claire Putt, Laura James, Jing Jin and 9 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Seroprevalence of SARS-CoV-2 antibodies among children receiving primary care in Toronto, Ontario.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
  3. Article
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  7. Observational
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  11. Seroprevalence of SARS-CoV-2 antibodies in front-line pediatric health care workers.Journal of the American College of Emergency Physicians open · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Karl W BoehmeDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0003-2691-9763
Joshua L KennedyDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jessica SnowdenDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-0715-151X
Shana M OwensDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Marianne KouassiDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Ryan L MannDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Amairani ParedesDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Claire PuttDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Laura JamesDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jing JinDepartment of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Ruofei DuDepartment of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Catherine KirkpatrickArkansas Children's Research Institute, Little Rock, Arkansas, USA.
Zeel ModiDepartment of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Katherine CaidArkansas Children's Research Institute, Little Rock, Arkansas, USA.
Sean YoungDepartment of Biostatistics, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-0054-0627
Namvar ZohooriDepartment of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Atul KothariDepartment of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Bobby L BoyantonDepartment of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
J Craig ForrestDepartment of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USArkansas Department of Health · USWinthrop Rockefeller Foundation · US

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
NCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1 TR003107NIGMS NIH HHS P20 GM103625NIH HHS P20 GM103625
6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence studies largely focus on adults, but little is known about spread in children. We determined SARS-CoV-2 seroprevalence in children and adolescents from Arkansas over the first year of the coronavirus disease of 2019 (COVID-19) pandemic.

methodsWe tested remnant serum samples from children ages 1-18 years who visited Arkansas hospitals or clinics for non-COVID-19-related reasons from April 2020 through April 2021 for SARS-CoV-2 antibodies. We used univariable and multivariable regression models to determine the association between seropositivity and participant characteristics.

resultsAmong 2357 participants, seroprevalence rose from 7.9% in April/May 2020 (95% CI, 4.9-10.9) to 25.0% in April 2021 (95% CI, 21.5-28.5). Hispanic and black children had a higher association with antibody positivity than non-Hispanic and white children, respectively, in multiple sampling periods.

conclusionsBy spring 2021, most children in Arkansas were not infected with SARS-CoV-2. With the emergence of SARS-CoV-2 variants, recognition of long-term effects of COVID-19, and the lack of an authorized pediatric SARS-CoV-2 vaccine at the time, these results highlight the importance of including children in SARS-CoV-2 public health, clinical care, and research strategies.

Indexed as

COVID-19PandemicsAdolescentAdultAntibodies, ViralArkansasChildChild, PreschoolCOVID-19 VaccinesHumansInfantSARS-CoV-2Seroepidemiologic StudiesAntibodies, ViralCOVID-19 VaccinesantibodychildchildrencoronavirusCOVID-19epidemiologyethnic disparityracial disparitySARS-CoV-2serologyserum

Identifiers

PMID35294550
PMCPMC8992271
OpenAlexW4210791831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.