ArticlePloS one2022
Metabolomics and transcriptomics unravel the mechanism of browning resistance in Agaricus bisporus.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- First genome report ofFrontiers in fungal biology · 2026Article
- Bio-digital feedback loop systems: a synergistic integration of predictive genomics, genome editing, and AI-driven phenomic synthesis for next-generation edible and medicinal mushroom breeding.Antonie van Leeuwenhoek · 2025Review
- A Review of Genomic, Transcriptomic, and Proteomic Applications in Edible Fungi Biology: Current Status and Future Directions.Journal of fungi (Basel, Switzerland) · 2025Review
- Metabolomic and Transcriptomic Analyses Revealed Lipid Differentiation Mechanisms inJournal of fungi (Basel, Switzerland) · 2024Article
- Novel Post-Harvest Preservation Techniques for Edible Fungi: A Review.Foods (Basel, Switzerland) · 2024Review
- Current Advances in the Functional Genes of Edible and Medicinal Fungi: Research Techniques, Functional Analysis, and Prospects.Journal of fungi (Basel, Switzerland) · 2024Review
- Metabolomics Profiling of White Button, Crimini, Portabella, Lion's Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis.Foods (Basel, Switzerland) · 2023Article
- Transcriptomic and Metabolomic Analyses Provide Insights into the Pathogenic Mechanism of the Rice False Smut PathogenInternational journal of molecular sciences · 2023Article
- High-quality genome assembly and multi-omics analysis of pigment synthesis pathway inFrontiers in microbiology · 2023Article
- Application of Metabolomics in Fungal Research.Molecules (Basel, Switzerland) · 2022Review
- Pseudo-Chromosomal Genome Assembly in Combination with Comprehensive Transcriptome Analysis inJournal of fungi (Basel, Switzerland) · 2022Article
- Edible and medicinal fungi breeding techniques, a review: Current status and future prospects.Current research in food science · 2022Review
- To become more sustainable organic agriculture needs genome editing technology.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
7 authors.
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Abstract
Agaricus bisporus is widely consumed on the world market. The easy browning of mushroom surface is one of the most intuitive factors affecting consumer purchase. A certain cognition on browning mechanism has been made after years of research. At present, people slow down the browning of mushrooms mainly by improving preservation methods. In addition, breeding is also a reliable way. In the production practice, we have identified some browning-resistant varieties, and we selected a browning-resistant variety to compare with an ordinary variety to reveal the resistance mechanism. Using transcriptomics and metabolomics, the differences in gene expression and metabolite levels were revealed, respectively. The results showed that differentially expressed genes (DEGs) like AbPPO4, AbPPO3 and AbPPO2 were differently expressed and these DEGs were involved in many pathways related to browning. The expression of AbPPO expression play an important role in the browning of A. bisporus and multiple PPO family members are involved in the regulation of browning. However, the resistance to browning cannot be judged only by the expression level of AbPPOs. For metabolomics, most of the different metabolites were organic acids. These organic acids had a higher level in anti-browning (BT) than easy-browning varieties (BS), although the profile was very heterogeneous. On the contrary, the content of trehalose in BS was significantly higher than that in BT. Higher organic acids decreased pH and further inhibited PPO activity. In addition, the BS had a higher content of trehalose, which might play roles in maintaining PPO activity. The difference of browning resistance between BS and BT is mainly due to the differential regulation mechanism of PPO.
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