Evidence map›Paper›PMID 35294328›Full record

ArticlePharmaceutical biology2021

Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from

Perwez Alam, Rama Tyagi, Mohammad Abul Farah, Md Tabish Rehman, Afzal Hussain, Mohamed Fahad AlAjmi, Nasir Ali Siddiqui, Khalid Mashay Al-Anazi, Saima Amin, Mohd Mujeeb and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Perwez AlamDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0003-0668-2236
Rama TyagiPhyto-Pharmaceutical Research Lab, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Mohammad Abul FarahDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0001-7616-7542
Md Tabish RehmanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Afzal HussainDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohamed Fahad AlAjmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Nasir Ali SiddiquiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Khalid Mashay Al-AnaziDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Saima AminDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Mohd MujeebDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Showkat R MirPhyto-Pharmaceutical Research Lab, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.ORCID 0000-0001-6394-5712
King Saud University · SAJamia Hamdard · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTraditionally,

objectiveTo isolate and characterize new cytotoxic phytoconstituents from MATERIALS AND

methodsThe column chromatography of

resultsThe isolated compound was identified as racemolactone I (compound

conclusionsRacemolactone I was identified as potential anticancer agent, which can further be confirmed by

Indexed as

A549 CellsAntineoplastic Agents, PhytogenicApoptosisCell Line, TumorCell SurvivalHeLa CellsHumansInulaLactonesMembrane Potential, MitochondrialMolecular Docking SimulationPlant RootsSesquiterpenesAntineoplastic Agents, PhytogenicLactonesSesquiterpenesapoptosisAsteraceaedimeric sesquiterpeneDNA damage detectionInula racemosa

Identifiers

PMID35294328
PMCPMC8274518
OpenAlexW3195530482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.