Evidence map›Paper›PMID 35294326›Full record

ArticlePharmaceutical biology2021

Cun Zhang, Yongwei Li, Changlong Yin, Jie Zheng, Guozhi Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Inhibitory effects of cornuside on human liver cytochrome P450 enzymes.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cun ZhangDepartment of Neonatology, Yidu Central Hospital of Weifang, Weifang, China.
Yongwei LiDepartment of Neonatology, Yidu Central Hospital of Weifang, Weifang, China.
Changlong YinDepartment of Neonatology, Yidu Central Hospital of Weifang, Weifang, China.
Jie ZhengDepartment of Neonatology, Yidu Central Hospital of Weifang, Weifang, China.
Guozhi LiuDepartment of Neonatology, Yidu Central Hospital of Weifang, Weifang, China.
Yidu Central Hospital of Weifang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPeucedanol is a major extract of

objectiveThe interaction between peucedanol and CYP450s was investigated. MATERIALS AND

methodsPeucedanol (0, 2.5, 5, 10, 25, 50, and 100 μM) was incubated with eight human liver CYP isoforms (CYP1A2, 2A6, 3A4, 2C8, 2C9, 2C19, 2D6, and 2E1), in pooled human liver microsomes (HLMs) for 30 min with specific inhibitors as positive controls and untreated HLMs as negative controls. The enzyme kinetics and time-dependent study (0, 5, 10, 15, and 30 min) were performed to obtain corresponding parameters

resultsPeucedanol significantly inhibited the activity of CYP1A2, 2D6, and 3A4 in a dose-dependent manner with IC DISCUSSION AND

conclusions

Indexed as

ApiaceaeChromansCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemPlant ExtractsDose-Response Relationship, DrugHumansInhibitory Concentration 50Microsomes, LiverTime FactorsChromansCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystempeucedanolPlant ExtractsCYP1A2CYP2D6CYP3A4drug-drug interaction

Identifiers

PMID35294326
PMCPMC8274509
OpenAlexW3180570082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.