ArticleScience advances2022
Improving SABRE hyperpolarization with highly nonintuitive pulse sequences: Moving beyond avoided crossings to describe dynamics.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Aliphatic chains as physical realizations of one-dimensional spin chains supporting magnetically silent spin waves.Science advances · 2026Article
- Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance.Science advances · 2026Article
- High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Ultra-low fieldCommunications chemistry · 2026Article
- Field Cycling from 10 nT to 9.4 T: A Flexible Gear Rod Design for Nuclear Spin Relaxation and Hyperpolarization Studies.ACS measurement science au · 2026Article
- Scalable modeling of multi-spin ensembles in SABRE hyperpolarization: a symmetry-based framework for zero and ultralow fields.Magnetic resonance (Gottingen, Germany) · 2026Article
- Direct detection of SABRE-SHEATH hyperpolarization and spin-lattice relaxation of [1-Communications chemistry · 2025Article
- Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025Article
- EfficientJournal of magnetic resonance open · 2025Article
- Development of a fully automated workstation for conducting routine SABRE hyperpolarization.Scientific reports · 2024Article
- Multi-axis fields boost SABRE hyperpolarization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Spin dynamics of [1,2-Physical chemistry chemical physics : PCCP · 2023Article
- Parahydrogen in Reversible Exchange Induces Long-LivedAnalytical chemistry · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-The journal of physical chemistry. A · 2022Article
- RapidAnalytical chemistry · 2022Article
- Multiaxial fields improve SABRE efficiency by preserving hydride order.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- SABRE enhancement with oscillating pulse sequences.Physical chemistry chemical physics : PCCP · 2022Article
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
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Authors and funding
4 authors.
Funding
Abstract
Signal amplification by reversible exchange (SABRE) creates "hyperpolarization" (large spin magnetization) using a transition metal catalyst and parahydrogen, addressing the sensitivity limitations of magnetic resonance. SABRE and its heteronuclear variant X-SABRE are simple, fast, and general, but to date have not produced polarization levels as large as more established methods. We show here that the commonly used theoretical framework for these applications, which focuses on avoided crossings (also called level anticrossings or LACs), steer current SABRE and X-SABRE experiments away from optimal solutions. Accurate simulations show astonishingly rich and unexpected dynamics in SABRE/X-SABRE, which we explain with a combination of perturbation theory and average Hamiltonian approaches. This theoretical picture predicts simple pulse sequences with field values far from LACs (both instantaneously and on average) using different terms in the effective Hamiltonian to strategically control evolution and improve polarization transfer. Substantial signal enhancements under such highly nonintuitive conditions are verified experimentally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.