ArticlemBio2022
Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Inactivation of MexT inJournal of bacteriology · 2026Article
- Regulatory mechanisms of quorum sensing in microbial communities and their potential applications in ruminant livestock production.Journal of advanced research · 2026Review
- Inactivation of MexT inbioRxiv : the preprint server for biology · 2025Article
- Quorum sensing modulates microbial community structure through regulation of secondary metabolites.mSphere · 2025Article
- Anti-infective synergy of3 Biotech · 2025Article
- Outer membrane permeability ofMicrobiology spectrum · 2025Article
- Co-regulation of cooperative and private traits by PsdR inEvolution letters · 2025Article
- An anticipatory mechanism enhances the cooperative behaviors of quorum sensing mutants in Pseudomonas aeruginosa.PLoS pathogens · 2025Article
- The relationship betweenJournal of bacteriology · 2024Article
- Targeted deletion of Pf prophages from diverseJournal of bacteriology · 2024Article
- Uncovering the GacS-mediated role in evolutionary progression through trajectory reconstruction in Pseudomonas aeruginosa.Nucleic acids research · 2024Article
- Uncovering a hidden functional role of the XRE-cupin protein PsdR as a novel quorum-sensing regulator in Pseudomonas aeruginosa.PLoS pathogens · 2024Article
- Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa.Molecular microbiology · 2024Article
- Relationship of the transcription factor MexT to quorum sensing and virulence inJournal of bacteriology · 2023Article
- A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing.Journal of bacteriology · 2023Article
- Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis.Nature communications · 2023Article
- Targeted deletion of Pf prophages from diversebioRxiv : the preprint server for biology · 2023Article
- Quorum sensing going wild.iScience · 2023Review
- Signatures of kin selection in a natural population of the bacteriaEvolution letters · 2023Article
- AmBio · 2023Article
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Authors and funding
6 authors.
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Abstract
In the opportunistic pathogenic bacterium Pseudomonas aeruginosa acyl-homoserine lactone quorum sensing (QS) can activate expression of dozens to hundreds of genes depending on the strain under investigation. Many QS-activated genes code for extracellular products. P. aeruginosa has become a model for studies of cell-cell communication and coordination of cooperative activities, which result from production of extracellular products. We hypothesized that strain variation in the size of the QS regulon might reflect the environmental history of an isolate. We tested the hypothesis by performing long-term growth experiments with the well-studied strain PAO1, which has a relatively large QS regulon, under conditions where only limited QS-controlled functions are required. We grew P. aeruginosa for about 1000 generations in a condition where expression of QS-activated genes was required, and emergence of QS mutants was constrained and compared the QS regulons of populations after 35 generations to those after about 1000 generations in two independent lineages by using quorum quenching and RNA-seq technology. In one lineage the number of QS-activated genes identified was reduced by over 60% and in the other by about 30% in 1000-generation populations compared to 35-generation populations. Our results provide insight about the variations in the number of QS-activated genes reported for different P. aeruginosa environmental and clinical isolates and, about how environmental conditions might influence social evolution.
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