Evidence map›Paper›PMID 35294219›Full record

ArticleScience robotics2022

Metabolically efficient walking assistance using optimized timed forces at the waist.

Prokopios Antonellis, Arash Mohammadzadeh Gonabadi, Sara A Myers, Iraklis I Pipinos, Philippe Malcolm

Abstract read
In one paragraph

Article in Science robotics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Perturbation-based estimation of within-stride cycle metabolic cost.Journal of neuroengineering and rehabilitation · 2024
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Prokopios AntonellisDepartment of Biomechanics and Center for Research in Human Movement Variability, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE 68182, USA.ORCID 0000-0002-8927-1274
Arash Mohammadzadeh GonabadiDepartment of Biomechanics and Center for Research in Human Movement Variability, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE 68182, USA.ORCID 0000-0002-4535-0325
Sara A MyersDepartment of Biomechanics and Center for Research in Human Movement Variability, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE 68182, USA.ORCID 0000-0002-2934-2624
Iraklis I PipinosDepartment of Surgery and Research Service, Veterans Affairs Nebraska-Western Iowa Medical Center, Omaha, NE 68105, USA.
Philippe MalcolmDepartment of Biomechanics and Center for Research in Human Movement Variability, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE 68182, USA.ORCID 0000-0003-4110-4167

Funding

Visual control of locomotion in people with Parkinsons diseaseP20GM109090 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI KNARR, BRIAN ANDREW · 2014 to 2023
$20.5M
Mitochondrial dysfunction, oxidative damage and inflammation in claudicationR01AG034995 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PIPINOS, IRAKLIS ILIAS · 2010 to 2014
$5.2M
Ramipril treatment of claudication: oxidative damage and muscle fibrosisR01AG049868 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASALE, GEORGE PASCO, PIPINOS, IRAKLIS ILIAS · 2015 to 2019
$4.7M
Improving mobility in peripheral artery disease using an ankle foot orthosisR01HD090333 · NICHD · UNIVERSITY OF NEBRASKA OMAHA · PI MYERS, SARA A · 2016 to 2020
$2.1M
Exoskeleton footwear to improve walking performance and subject-reported preference.I01RX003266 · VA · OMAHA VA MEDICAL CENTER · PI MYERS, SARA A, PIPINOS, IRAKLIS ILIAS · 2020 to 2024
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NIA NIH HHS R01 AG034995NIA NIH HHS R01 AG049868NICHD NIH HHS R01 HD090333NIGMS NIH HHS P20 GM109090RRD VA I01 RX003266
6 · The paper itself

Abstract

The metabolic rate of walking can be reduced by applying a constant forward force at the center of mass. It has been shown that the metabolically optimal constant force magnitude minimizes propulsion ground reaction force at the expense of increased braking. This led to the hypothesis that selectively assisting propulsion could lead to greater benefits. We used a robotic waist tether to evaluate the effects of forward forces with different timings and magnitudes. Here, we show that it is possible to reduce the metabolic rate of healthy participants by 48% with a greater efficiency ratio of metabolic cost reduction per unit of net aiding work compared with other assistive robots. This result was obtained using a sinusoidal force profile with peak timing during the middle of the double support. The same timing could also reduce the metabolic rate in patients with peripheral artery disease. A model explains that the optimal force profile accelerates the center of mass into the inverted pendulum movement during single support. Contrary to the hypothesis, the optimal force timing did not entirely coincide with propulsion. Within the field of wearable robotics, there is a trend to use devices to mimic biological torque or force profiles. Such bioinspired actuation can have relevant benefits; however, our results demonstrate that this is not necessarily optimal for reducing metabolic rate.

Indexed as

GaitRoboticsBiomechanical PhenomenaHumansTorqueWalking

Identifiers

PMID35294219
PMCPMC9367670

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.