Evidence map›Paper›PMID 35294135›Full record

ReviewJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2022

Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and ClinicalTrials.gov: a narrative review.

Jing-Jing Wei, Rong-Juan Guo, Guo-Jing Fu, Xiao Liang, Zhen-Min Xu, Min Jia, Zi-Xiu Zeng, Wan-Qing Du, Wei-Wei Jiao, Lin-Juan Sun and 5 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02275949 (The Efficacy and Safety of Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02275949 nacompletednot on this map

The Efficacy and Safety of Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage

TypeinterventionalSponsorKyung Hee University Hospital at GangdongRan2014 to 2017Enrolled50ConditionsSAH (Subarachnoid Hemorrhage), Cerebral VasospasmArmsacupuncture, Electroacupuncture, Intradermal acupuncture, Mock transcutaneous electrical nerve stimulation, sham intradermal acupuncture
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing-Jing WeiGraduate school, Beijing University of Chinese Medicine, Beijing 10029, China.
Rong-Juan GuoDepartment of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Guo-Jing FuDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Xiao LiangDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhen-Min XuGraduate school, Beijing University of Chinese Medicine, Beijing 10029, China.
Min JiaDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zi-Xiu ZengGraduate school, Beijing University of Chinese Medicine, Beijing 10029, China.
Wan-Qing DuGraduate school, Beijing University of Chinese Medicine, Beijing 10029, China.
Wei-Wei JiaoDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Lin-Juan SunDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Hong-Mei LiuDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Chun-Li GuoDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Chen-Guang TongDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Yun-Ling ZhangDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Xing LiaoCenter for Evidence Based Chinese Medicine, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the current status of clinical trial registration of Traditional Chinese Medicine (TCM) for the treatment of neurological diseases.

methodsInterventional clinical trials of TCM treatment for ischemic stroke, hemorrhagic stroke, vascular cognitive impairment, tension-type headache before September 22, 2020 on the platform of Chinese Clinical Trial Registry (ChiCTR), and ClinicalTrials.gov were searched. Two researchers independently selected the literature and extracted data.

resultsA total of 180 interventional clinical trials were included for analysis. Out of 180 trials, 127 were from ChiCTR and 53 from ClinicalTrials.gov. The countries primary sponsoring the included trials were China (176, 97.8%), and the common categories of primary sponsors were hospital (131, 72.8%). Among the study design, the largest proportion of allocation was randomized (172, 95.6%), interventional model assignment was parallel (163, 90.6%), masking was double blind 49 (27.2%), and the sample size was ≤ 400 (144, 80.0%). The trials were most carried out at a single center (102, 56.7%). Among the included studies, 112 (62.2%) registered on ChiCTR attached the ethical approval documents. In terms of trial stages, 50 (27.7%) studies were in phase IV. The mostly used intervention was Chinese herbal medicines (99, 55%), acupuncture (68, 37.8%) was the second. By searching the registration number on China National Knowledge Infrastructure Database and PubMed, 38 (21.1%) registered trials were published, including 25 protocol studies and 14 research results with one (NCT02275949) published both the protocol and the results.

conclusionsIrregular and inadequate reporting, untimely update and publication, insufficient information on traditional medicine unique characteristics, and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases. More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.

Indexed as

AcupunctureAcupuncture TherapyDrugs, Chinese HerbalHumansMedicine, Chinese TraditionalRandomized Controlled Trials as TopicRegistriesResearch DesignDrugs, Chinese HerbalChinese Clinical Trial RegistryClinicalTrials.govCognitive dysfunctionCritical appraisalHemorrhagic strokeIschemic strokeMedicine, Chinese traditionalTension-type headache

Identifiers

PMID35294135
PMCPMC10164634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.