Evidence map›Paper›PMID 35294128›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2022

Gut microbiota and differential genes-maintained homeostasis is key to maintaining health of individuals with Yang-deficiency constitution.

Hui-Xiang Zhang, Li-Mei Wang, Ji-Peng Guo, Ji-Ai Wang, Qian-Qian Zhang, Yu-Tao Wang, Xun Liu, Li-Huan Zhang, Lan-Lan Shi, Hong-Xiang Wu and 1 more

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hui-Xiang ZhangInstitute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming 650500, China.
Li-Mei WangDepartment of Laboratory Animal Science, Kunming Medical University, Kunming 650500, China.
Ji-Peng GuoSchool of Electrical and Information Technology, Yunnan Minzu University, Kunming 650500, China.
Ji-Ai WangSchool of Medicine, Kunming University, Kunming 650214, China.
Qian-Qian ZhangBasic Medical College, Kunming Medical University, Kunming 650500, China.
Yu-Tao WangBasic Medical College, Kunming Medical University, Kunming 650500, China.
Xun LiuBasic Medical College, Kunming Medical University, Kunming 650500, China.
Li-Huan ZhangDepartment of Laboratory Animal Science, Kunming Medical University, Kunming 650500, China.
Lan-Lan ShiDepartment of Anatomy, Histology and Embryology, Basic Medical College, Kunming Medical University, Kunming 650500, China.
Hong-Xiang WuFaculty of Rehabilitation Medicine, Kunming Medical University, Kunming 650500, China.
Xue CaoDepartment of Laboratory Animal Science, Kunming Medical University, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650500, China.
Kunming Medical University · CNKunming University · CNMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveYang-deficiency constitution (YADC) is a common unbalanced constitution that predisposes individuals to certain diseases. However, not all people with YADC manifest develop diseases. This calls for delineation of the underlying molecular mechanisms. Previous studies suggested that the gut microbiota and gene differential expression should be considered.

methodsIn the present study, we compared profiles of gut microbiota between four healthy YADC individuals and those of five healthy balanced constitution (BC) counterparts, based on 16S rRNA gene sequence analysis. Furthermore, YADC relevant genes identified by comparing 62 healthy YADC and 58 healthy BC individuals in total to perform intersection analysis, functional clustering and pathway enrichment analyses.

resultsThe levels of harmful gut microbiota (Prevotellaceae, LDA score > 4.0, P = 0.0141) and beneficial gut microbiota (Ruminococcaceae, LDA score > 4.0, P = 0.0025, Faecalibacterium, LDA score > 4.0, P = 0.0484) were both elevated in healthy YADC individuals. Also, we found that the specific metabolic pathway with 2, 6-Dichloro-p-hydroquinone 1, 2-Dioxygenase (PcpA) as the core in gut microbiota and the glutathione transferase activity has been enriched by YADC relevant genes in healthy YADC individuals were both responsible for the detoxification of halogenated aromatic hydrocarbon substances.

conclusionsBoth beneficial and harmful factors had been detected in healthy YADC individuals, functionally, they may have triggered homeostasis to maintain the health of individuals with YADC. The homeostasis may be maintained by beneficial and harmful factors from gut flora and genes. Future studies are expected to focus on halogenated aromatic hydrocarbons and their detoxification processes.

Indexed as

Gastrointestinal MicrobiomeHomeostasisHumansRNA, Ribosomal, 16SYang DeficiencyRNA, Ribosomal, 16SGastrointestinal microbiomeGeneHealth promotionHomeostasiHydrocarbons, aromaticPhysical constitution theoryYang deficiency

Identifiers

PMID35294128
PMCPMC10164632
OpenAlexW4220785499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.