ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2022
Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI-Based Meta-Analysis.Annals of the New York Academy of Sciences · 2026Pooled it
- A Generalized Approach to Solving Deep Learning-Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes.Magnetic resonance in medicine · 2026Article
- Reproducibility of QQ (QSM + qBOLD) Oxygen Extraction Fraction (OEF) Mapping in the Brain at 3 and 1.5 T.Magnetic resonance in medicine · 2026Article
- Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.Brain communications · 2026Article
- Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer's disease and non-Alzheimer's dementias.Frontiers in neuroscience · 2026Article
- Cerebral oxygen extraction fraction as an emerging imaging biomarker in mild cognitive impairment and dementia.Dementia & neuropsychologia · 2026Review
- Oxygen extraction fraction mapping between normal cognition and mild cognitive impairment in older adults using quantitative BOLD.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression.Brain : a journal of neurology · 2025Article
- Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Review
- Article
- Cerebral oxygen metabolism from MRI susceptibility.NeuroImage · 2023Review
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- Decreased cerebral metabolic rate of oxygen (CMROAlzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeWe investigated the effects of aging, white matter hyperintensities (WMH), and cognitive impairment on brain iron levels and cerebral oxygen metabolism, known to be altered in Alzheimer's disease (AD), using quantitative susceptibility mapping and MR-based cerebral oxygen extraction fraction (OEF).
methodsIn 100 individuals over the age of 50 (68/32 cognitively impaired/intact), OEF and neural tissue susceptibility (χ
resultsCognitively impaired subjects were found to have 19% higher OEF and 34% higher χ
conclusionsHigher brain OEF and χ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.