ArticleClinical cardiology2022
Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy.
Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Left Atrial Function in Children with Cancer Prior to Start of Chemotherapy: A Speckle Echocardiography Analysis.Pediatric cardiology · 2026Article
- Imaging in Cardio-Oncology: Role of Novel Echo Parameters in Breast Cancer and Gynecologic Malignancies.Current cardiology reports · 2026Review
- Advances in cardiac ultrasound speckle tracking technology for assessing left ventricular systolic function after adjuvant radiotherapy following breast-conserving surgery for breast cancer.American journal of translational research · 2025Review
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- Superiority of left heart deformation in early anthracycline-related cardiac dysfunction detection.Open heart · 2023Article
- Challenges in Cardiovascular Imaging in Women with Breast Cancer.Current cardiology reports · 2023Review
- Assessment of left heart dysfunction to predict doxorubicin cardiotoxicity in children with lymphoma.Frontiers in pediatrics · 2023Article
- Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy.Clinical cardiology · 2022Article
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13 authors.
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Abstract
backgroundLeft atrial (LA) function and mechanical dispersion changes in breast cancer patients treated with chemotherapy remain unclear. HYPOTHESIS: LA function and LA mechanical dispersion in breast cancer patients would be impaired after chemotherapy.
methodsThis single-center retrospective study included 91 consecutive breast cancer patients treated with chemotherapy and 30 controls. Patients were examined by echocardiography three times at intervals. Conventional parameters, left ventricular strain, LA strain, and LA mechanical dispersion were evaluated and compared.
resultsLA strain during reservoir phase (LASr), conduit phase (LAScd), and contraction phase (LASct) all decreased markedly after chemotherapy and were lower than those of the controls (all p < .01). The standard deviation of time to peak positive strain during LA reservoir phase corrected by R-R interval (LA SD-TPSr) was significantly increased after chemotherapy and was higher than that of the controls (p < .001). The change of LA function was expressed as Δ. Multivariate linear regression analyses showed that LAVIp (0.399, 95% confidence interval [CI]: 0.610, 1.756, p = .000) was independently associated with ΔLASr, LAPEF (-0.325, 95% CI: -45.123, -10.676, p = .002) and age (0.227, 95% CI: 0.021, 0.350, p = .027) were independently associated with ΔLAScd, and LAVImax (0.341, 95% CI: 0.192, 0.723, p = .001) was independently associated with ΔLASct. LAVImax (0.505, 95% CI: 0.000, 0.001, p = .039) and mitral E (-0.256, 95% CI: 0.000, 0.000, p = .024）were independently associated with ΔLA SD-TPSr.
conclusionsMechanical function of LA declined after chemotherapy in breast cancer patients. With the decrease of LA mechanical function, LA mechanical dispersion assessed by two-dimensional speckle-tracking echocardiography increased significantly, and its clinical value needs to be further studied.
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