ArticleJournal of experimental botany2022
MtGSTF7, a TT19-like GST gene, is essential for accumulation of anthocyanins, but not proanthocyanins in Medicago truncatula.
Article in Journal of experimental botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Genome-wide characterization of the glutathione S-transferase gene family identifies GmGSTF8 and GmGSTF11 as anthocyanin-associated GSTs in soybean.BMC plant biology · 2026Article
- The mitochondrial DnaJA protein LMA1 regulates reactive oxygen species homeostasis and anthocyanin biosynthesis inPlant diversity · 2026Article
- The vacuolar transporters MaMATE11 and MaMATE14 affect blue flower coloration in grape hyacinth (Horticulture research · 2026Article
- Integrated metabolome and transcriptome analysis provides insights into anthocyanin biosynthesis in Portulaca oleracea.BMC plant biology · 2025Article
- First interspecific multi-parent advanced generation inter-cross (MAGIC) population inHorticulture research · 2025Article
- SbC1, an R2R3-MYB transcription factor, specifically regulates anthocyanin accumulation in sorghum coleoptiles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- cDNA Cloning, Bioinformatics, and Expression Analysis ofInternational journal of molecular sciences · 2025Article
- Overlooked and misunderstood: can glutathione conjugates be clues to understanding plant glutathione transferases?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Integrated Analyses of Metabolome and RNA-seq Data Revealing Flower Color Variation in OrnamentalGenes · 2024Article
- Downregulation of a Phi class glutathionePlant biotechnology (Tokyo, Japan) · 2024Article
- Identification and Characterization of the Glutathione S-Transferase Gene Family in Blueberry (Plants (Basel, Switzerland) · 2024Article
- A chromosome-level genome assembly for Onobrychis viciifolia reveals gene copy number gain underlying enhanced proanthocyanidin biosynthesis.Communications biology · 2024Article
- Transcription factor NnMYB5 controls petal color by regulating GLUTATHIONE S-TRANSFERASE2 in Nelumbo nucifera.Plant physiology · 2023Article
- The Role of Anthocyanins in Plant Tolerance to Drought and Salt Stresses.Plants (Basel, Switzerland) · 2023Review
- The complexities of proanthocyanidin biosynthesis and its regulation in plants.Plant communications · 2023Review
- The flexibility of proanthocyanidin biosynthesis in plants.Plant physiology · 2022Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
Anthocyanins and proanthocyanins (PAs) are two end products of the flavonoid biosynthesis pathway. They are believed to be synthesized in the endoplasmic reticulum and then sequestered into the vacuole. In Arabidopsis thaliana, TRANSPARENT TESTA 19 (TT19) is necessary for both anthocyanin and PA accumulation. Here, we found that MtGSTF7, a homolog of AtTT19, is essential for anthocyanin accumulation but not required for PA accumulation in Medicago truncatula. MtGSTF7 was induced by the anthocyanin regulator LEGUME ANTHOCYANIN PRODUCTION 1 (LAP1), and its tissue expression pattern correlated with anthocyanin deposition in M. truncatula. Tnt1-insertional mutants of MtGSTF7 lost anthocyanin accumulation in vegetative organs, and introducing a genomic fragment of MtGSTF7 could complement the mutant phenotypes. Additionally, the accumulation of anthocyanins induced by LAP1 was significantly reduced in mtgstf7 mutants. Yeast-one-hybridization and dual-luciferase reporter assays revealed that LAP1 could bind to the MtGSTF7 promoter to activate its expression. Ectopic expression of MtGSTF7 in tt19 mutants could rescue their anthocyanin deficiency, but not their PA defect. Furthermore, PA accumulation was not affected in the mtgstf7 mutants. Taken together, our results show that the mechanism of anthocyanin and PA accumulation in M. truncatula is different from that in A. thaliana, and provide a new target gene for engineering anthocyanins in plants.
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