Evidence map›Paper›PMID 35293996›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV.

Jenny Pena Dias, Damani A Piggott, Jing Sun, Leen Wehbeh, Joshua Garza, Alison Abraham, Jacquie Astemborski, Kendall F Moseley, Shehzad Basaria, Ravi Varadhan and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jenny Pena DiasDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-8171-0543
Damani A PiggottDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jing SunDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-3741-0962
Leen WehbehDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-6045-0706
Joshua GarzaDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Alison AbrahamDepartment of Epidemiology Johns Hopkins Bloomberg School of Public Health; Department of Epidemiology, School of Public Health and Department of Ophthalmology, School of Medicine, University of Colorado Anschutz Medical Campus, Colorado, USA.
Jacquie AstemborskiDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Kendall F MoseleyDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Shehzad BasariaBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1749-8549
Ravi VaradhanDepartment of Oncology; Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-8434-1034
Todd T BrownDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8599-278X
Johns Hopkins University · USBrigham and Women's Hospital · USUniversity of Colorado Anschutz Medical Campus · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
The Impact of HCV Infection on Bone Turnover, Density, and StrengthR01AI120733 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T · 2016 to 2020
$3.7M
Mentoring in Endocrine and Metabolic Abnormalities in HIV and AgingK24AI120834 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T · 2015 to 2025
$1.8M
Collaboration on HIV and AgingResearch through the Study of MitochondriaK01AI162247 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Jing Sun · 2022 to 2026
$677k
NCATS NIH HHS UL1 TR003098NIAID NIH HHS K01 AI162247NIAID NIH HHS K24 AI120834NIAID NIH HHS R01 AI120733NIDA NIH HHS U01 DA036297NIH HHSNIST DOC U01DA036297
6 · The paper itself

Abstract

contextSex hormone-binding globulin (SHBG) is a glycoprotein that regulates the bioavailability of sex hormones and is higher in people with HIV (PWH) and hepatitis C virus (HCV). SHBG is associated with aging-related diseases, including osteoporosis and frailty in the general population. However, the relationship between SHBG concentration and bone mineral density (BMD) and physical function among PWH and HCV is unclear.

objectiveThis study aimed to evaluate the association between chronic infection with HIV and HCV and SHBG, and to assess the relationship of circulating SHBG concentrations with low BMD, physical function impairment, and frailty.

methodsA cross-sectional study was conducted of 278 HCV-exposed (HCV antibody positive) adults enrolled with and without HIV and HCV from the AIDS Linked to the IntraVenous Experience cohort study into 4 groups: HCV-/HIV-, HCV-/HIV+, HCV+/HIV-, and HCV+/HIV+. We evaluated the association between SHBG concentrations and grip strength, gait speed, Short Physical Performance Battery score, frailty (Fried Frailty Phenotype), and BMD (lumbar spine, total hip, and femoral neck T-score) by using adjusted multivariable regression stratified by sex.

resultsSHBG concentrations were higher in women, in those with HIV RNA greater than 400 copies/mL (P = .02) and HCV RNA greater than 15 IU/mL (P < .001). In adjusted models, higher SHBG concentrations among women were statistically significantly associated with lower grip strength (-0.43 [95% CI, -0.77 to -0.081] kg/10 nmol/L, P < .05), higher odds of frailty (odds ratio, 1.49 [95% CI, 1.07 to 2.08], P < .05), and lower T-scores at the lumbar spine (-0.070 [95% CI, -0.15 to -0.001] SD/10 nmol/L T-score BMD, P < .05). Similar associations were not observed among men.

conclusionHigher SHBG concentrations are associated with the presence of HIV and HCV viremia. Among women, but not men, higher SHBG concentrations were associated with lower grip strength, higher odds of frailty, and lower lumbar spine BMD. The underlying mechanisms of these associations require further investigation.

Indexed as

Bone DensityDrug UsersHepatitis CHIV InfectionsSex Hormone-Binding GlobulinCohort StudiesCross-Sectional StudiesFemaleFrailtyHand StrengthHepacivirusHumansMaleSex Hormone-Binding Globulinaging-related diseasesHCVHIVSHBG

Identifiers

PMID35293996
PMCPMC9202730
OpenAlexW4220875996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.