Evidence map›Paper›PMID 35293903›Full record

ArticleMaterials horizons2022

Selective treatment of intracellular bacterial infections using host cell-targeted bioorthogonal nanozymes.

Joseph Hardie, Jessa Marie Makabenta, Aarohi Gupta, Rui Huang, Roberto Cao-Milán, Ritabrita Goswami, Xianzhi Zhang, Parvati Abdulpurkar, Michelle E Farkas, Vincent M Rotello

Open access · greenAbstract read
In one paragraph

Article in Materials horizons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Article
  8. Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Bioorthogonal nanozymes for breast cancer imaging and therapy.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Joseph HardieDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Jessa Marie MakabentaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.ORCID 0000-0002-2062-7914
Aarohi GuptaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.ORCID 0000-0003-1303-1159
Rui HuangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Roberto Cao-MilánDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Ritabrita GoswamiDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Xianzhi ZhangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Parvati AbdulpurkarDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Michelle E FarkasDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.ORCID 0000-0001-5824-1243
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.ORCID 0000-0002-5184-5439
University of Massachusetts Amherst · US

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated MacrophagesR01EB022641 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2017 to 2024
$3.0M
NIAID NIH HHS R01 AI134770NIBIB NIH HHS R01 EB022641NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Intracellular bacterial infections are difficult to treat, and in the case of

Indexed as

Bacterial InfectionsMetal NanoparticlesAnti-Bacterial AgentsCiprofloxacinGoldHumansSalmonella typhimuriumAnti-Bacterial AgentsCiprofloxacinGold

Identifiers

PMID35293903
PMCPMC9090992
OpenAlexW4220791349

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.