ArticleeLife2022
Minimal requirements for a neuron to coregulate many properties and the implications for ion channel correlations and robustness.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes.Scientific reports · 2026Article
- Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances.eLife · 2025Article
- Advances in magnetic field approaches for non-invasive targeting neuromodulation.Frontiers in human neuroscience · 2025Review
- Neural Processing without OPhysiology (Bethesda, Md.) · 2024Review
- Article
- Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Controlling morpho-electrophysiological variability of neurons with detailed biophysical models.iScience · 2023Article
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models.Scientific reports · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Different parameter solutions of a conductance-based model that behave identically are not necessarily degenerate.Journal of computational neuroscience · 2023Review
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Neurons regulate their excitability by adjusting their ion channel levels. Degeneracy - achieving equivalent outcomes (excitability) using different solutions (channel combinations) - facilitates this regulation by enabling a disruptive change in one channel to be offset by compensatory changes in other channels. But neurons must coregulate many properties. Pleiotropy - the impact of one channel on more than one property - complicates regulation because a compensatory ion channel change that restores one property to its target value often disrupts other properties. How then does a neuron simultaneously regulate multiple properties? Here, we demonstrate that of the many channel combinations producing the target value for one property (the single-output solution set), few combinations produce the target value for other properties. Combinations producing the target value for two or more properties (the multioutput solution set) correspond to the intersection between single-output solution sets. Properties can be effectively coregulated only if the number of adjustable channels (
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