Evidence map›Paper›PMID 35293622›Full record

ArticleAnnals of neurology2022

Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Johanna Oechtering, Therese Lincke, Sabine Schaedelin, Bernhard F Décard, Aleksandra Maceski, Annette Orleth, Stephanie Meier, Eline Willemse, Arabella Buchmann, Michael Khalil and 17 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Complement Activation Is Associated With Disease Severity in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 2 countries.

Johanna OechteringNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Therese LinckeDivision of Neuroradiology, Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Sabine SchaedelinResearch Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital and University of Basel, Basel, Switzerland.
Bernhard F DécardNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Aleksandra MaceskiNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Annette OrlethNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Stephanie MeierNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Eline WillemseNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Arabella BuchmannNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Michael KhalilDepartment of Neurology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-5350-3328
Tobias DerfussNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Pascal BenkertResearch Center for Clinical Neuroimmunology and Neuroscience (RC2NB), University Hospital and University of Basel, Basel, Switzerland.
Ingmar HeijnenDivision of Medical Immunology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Axel RegeniterMedica Laboratory, Zürich, Switzerland.
Stefanie MüllerDepartment of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Lutz AchtnichtsDepartment of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland.
Patrice LaliveDepartment of Clinical Neurosciences, Division of Neurology, Geneva University Hospital, Geneva, Switzerland.
Anke SalmenDepartment of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Caroline PotDivision of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Claudio GobbiNeurocentre of Southern Switzerland, Multiple Sclerosis Centre, Ospedale Civico, Lugano, Switzerland.
Ludwig KapposNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Cristina GranzieraNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
David LeppertNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Regina SchlaegerNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0003-2056-5765
Johanna M LiebDivision of Neuroradiology, Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Jens KuhleNeurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-6963-8892
Swiss MS Cohort Study
University of Basel · CHKantonsspital Aarau · CHMedical University of Graz · ATOspedale regionale di Lugano · CHUniversity Hospital of Basel · CHUniversity of Bern · CHUniversity of Geneva · CHUniversity of Lausanne · CHUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIntrathecal Immunoglobulin M synthesis (IgM

methodsIn 122 patients with a first demyelinating event associations between (1) spinal versus (vs) non-spinal clinical syndrome (2) spinal vs cerebral T2-weighted (T2w) and (3) contrast-enhancing (CE) lesion counts with IgG

resultsPatients with a spinal syndrome had a 8.36-fold higher odds of IgM

interpretationIntrathecal IgM synthesis is strongly associated with spinal manifestation and independently more pronounced neuroaxonal injury in early MS, suggesting a distinct clinical phenotype and pathophysiology. ANN NEUROL 2022;91:814-820.

Indexed as

Multiple SclerosisOligoclonal BandsHumansImmunoglobulin GImmunoglobulin MSpinal CordImmunoglobulin GImmunoglobulin MOligoclonal Bands

Identifiers

PMID35293622
PMCPMC9320956
OpenAlexW4220861268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.