Evidence map›Paper›PMID 35293604›Full record

ArticleMolecular neurobiology2022

The Role of Zinc in Axon Formation via the mTORC1 Pathway.

Seunghyuk Choi, Donghyeon Kang, Jieun Kang, Dae Ki Hong, Beom Seok Kang, A Ra Kho, Bo Young Choi, Sung-Oh Huh, Sang Won Suh

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Seunghyuk ChoiDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Donghyeon KangDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Jieun KangDepartment of Pharmacology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Dae Ki HongDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Beom Seok KangDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
A Ra KhoDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Bo Young ChoiDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Sung-Oh HuhDepartment of Pharmacology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea.
Sang Won SuhDepartment of Physiology, College of Medicine, Hallym University, Hallymdaehak-gil 1, Chuncheon, 24252, Republic of Korea. swsuh@hallym.ac.kr.ORCID http://orcid.org/0000-0002-7492-579X
Hallym University · KR

Funding

Korea Dementia Research Center (KDRC), funded by the Ministry of Health &Welfare and Ministry of Science and ICT HU20C0206National Research Foundation of Korea NRF-2020R1A2C2008480National Research Foundation of Korea NRF- 2020R1I1A1A01072653National Research Foundation of Korea NRF-2021R1A2C1005395
6 · The paper itself

Abstract

Zinc is an essential micronutrient required for proper function during neuronal development because it can modulate neuronal function and structure. A fully functional description of zinc in axonal processing in the central nervous system remains elusive. Here, we define the role of intracellular zinc in axon formation and elongation, involving the mammalian target of rapamycin complex 1 (mTORC1). To investigate the involvement of zinc in axon growth, we performed an ex vivo culture of mouse hippocampal neurons and administrated ZnCl

Indexed as

AxonsZincAnimalsMammalsMechanistic Target of Rapamycin Complex 1MiceNeuronsSignal TransductionMechanistic Target of Rapamycin Complex 1ZincAxonmTORC1Primary neuronZinc

Identifiers

PMID35293604
OpenAlexW4220866052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.