SynthesisArquivos de neuro-psiquiatria2022
Sleep disorders in Down syndrome: a systematic review.
Synthesis in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Sleep Disturbance and its Relationship with Behavioral Problems in Children with Down's Syndrome - A Cross-Sectional Study.Indian journal of pediatrics · 2026Article
- Multidimensional Sleep Health of Toddlers With Down Syndrome: A Descriptive Study Guided by the Pediatric Sleep Health Framework.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2026Article
- Restoring RCAN1 dosage mitigates sleep and EEG abnormalities in a Down syndrome model.Neurobiology of disease · 2026Article
- Behavioral Sleep Interventions for Neurodivergent Youth: A Narrative Review.Current sleep medicine reports · 2026Review
- Mapping the Fat: How Childhood Obesity and Body Composition Shape Obstructive Sleep Apnoea.Children (Basel, Switzerland) · 2025Review
- NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model.iScience · 2025Article
- Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?Aging and disease · 2025Review
- Carbonyl reductase 1: a novel regulator of blood pressure in Down syndrome.Bioscience reports · 2025Article
- Sleep Fragmentation in TcMAC21 Mouse Model of Down Syndrome.Nature and science of sleep · 2025Article
- Observational
- Role of leisure and sleep in promoting daily physical activity in adults with down syndrome.Health psychology and behavioral medicine · 2025Article
- Article
- Article
- Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing in Children.Children (Basel, Switzerland) · 2024Review
- Expression profile of inflammasome genes in individuals with Down syndrome.Genetics and molecular biology · 2024Article
- Sleep assessment in adults with Down syndrome: correlation between functionality and polysomnographic findings.Arquivos de neuro-psiquiatria · 2023Article
- Parental perception of facilitators and barriers to health among young children with down syndrome: a qualitative study.Frontiers in pediatrics · 2023Article
- Sleep and behavioral problems in Down syndrome: differences between school age and adolescence.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disorders are commonly observed in children with Down syndrome (DS) and can lead to significant behavioral and cognitive morbidities in these individuals.
objectiveTo perform a systematic review evaluating sleep disorders in individuals with DS.
methodsSearch strategies were based on combinations of keywords: "Down syndrome"; "trisomy 21"; "sleep disorders"; "dyssomnias"; "sleep apnea"; "obstructive"; "sleeplessness"; "insomnia"; "parasomnias"; and "excessive daytime sleepiness". PubMed and Science Direct were used. Only original studies and retrospective reviews in English published between January 2011 and March 2021 were included.
results52 articles were included, most of them involving children and adolescents under 18 years of age. The main sleep disorder associated with DS was obstructive sleep apnea (OSA). Some studies reported the presence of cognitive dysfunction in patients with DS and sleep-disordered breathing, and few have been found about parasomnia, insomnia, and daytime sleepiness in these patients. Movement disorders and unusual postures during sleep may be related to disordered sleep breathing in DS. The main treatment options for OSA are continuous positive airway pressure therapy (CPAP), surgery, and weight control. Computational modeling associated with MRI has been used to plan surgical interventions in these patients.
conclusionsIndividuals with DS are at high risk of developing sleep-related breathing disorders. The main sleep disorder associated with DS was OSA. The presence of sleep-disordered breathing contributes to a worsening of cognitive function in patients with DS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.