Evidence map›Paper›PMID 35293228›Full record

ArticleHuman gene therapy2022

Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck.

Olympia Bikou, Serena Tharakan, Kelly P Yamada, Taro Kariya, Jaume Aguero, Alexandra Gordon, Renata Mazurek, Tadao Aikawa, Erik Kohlbrenner, Kenneth M Fish and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.Molecular therapy. Methods & clinical development · 2024
    Article
  2. Histamine activates an intracellular CaFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Olympia BikouCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Serena TharakanCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kelly P YamadaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Taro KariyaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jaume AgueroCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Alexandra GordonCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Renata Mazurek
Tadao AikawaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Erik Kohlbrenner
Kenneth M FishCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Roger J HajjarPhospholamban Foundation, Amsterdam, Netherlands.
Kiyotake IshikawaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8287-3483
Icahn School of Medicine at Mount Sinai · US

Funding

TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6M
Percutaneous Left Ventricular Unloading for Cardiogenic Shock: Beyond Acute Hemodynamic SupportR01HL139963 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kiyotake Ishikawa · 2018 to 2026
$4.9M
NHLBI NIH HHS R01 HL139963NHLBI NIH HHS T32 HL007824
6 · The paper itself

Abstract

A disappointing number of new therapies for pulmonary hypertension (PH) have been successfully translated to the clinic. Adeno-associated viral (AAV) gene therapy has the potential to treat the underlying pathology of PH, but the challenge remains in efficient and safe delivery. The aims of this study were (1) to test the efficacy of endobronchial aerosolization delivery for AAV1-mediated sarcoplasmic/endoplasmic reticulum Ca

Indexed as

Hypertension, PulmonaryAnimalsDependovirusGenetic TherapyGenetic VectorsGene Transfer TechniquesLungSarcoplasmic Reticulum Calcium-Transporting ATPasesSwineSarcoplasmic Reticulum Calcium-Transporting ATPasesAAVairway deliverybronchoscopelarge animalpulmonary hypertension

Identifiers

PMID35293228
PMCPMC9142769
OpenAlexW4220891668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.