ArticleJournal of biomedical optics2022
Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- A virtual imaging framework for three-dimensional quantitative optoacoustic tomography using stochastic numerical breast phantoms.Photoacoustics · 2026Article
- Application of a virtual imaging framework for investigating a deep learning-based reconstruction method for 3D quantitative photoacoustic computed tomography.Photoacoustics · 2026Article
- Learning a Filtered Backprojection Reconstruction Method for Photoacoustic Computed Tomography With Hemispherical Measurement Geometries.IEEE transactions on medical imaging · 2026Article
- Non-Invasive Photoacoustic Cerebrovascular Monitoring of Early-Stage Ischemic Strokes In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 3D Multiparametric Photoacoustic Computed Tomography of Primary and Metastatic Tumors in Living Mice.ACS nano · 2024Article
- Monte Carlo-Based Optical Simulation of Optical Distribution in Deep Brain Tissues Using Sixteen Optical Sources.Bioengineering (Basel, Switzerland) · 2024Article
- Quantitative photoacoustic tomography: modeling and inverse problems.Journal of biomedical optics · 2024Review
- Deep tissue photoacoustic imaging with light and sound.Npj imaging · 2024Review
- In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice.Nature communications · 2023Article
- A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption.Photoacoustics · 2023Review
- Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer.Journal of biomedical optics · 2023Article
- Periodic-net: an end-to-end data driven framework for diffuse optical imaging of breast cancer from noisy boundary data.Journal of biomedical optics · 2023Article
- In vivo quantitative photoacoustic evaluation of the liver and kidney pathology in tyrosinemia.Photoacoustics · 2022Article
- Adaptive dual-speed ultrasound and photoacoustic computed tomography.Photoacoustics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
significanceIn three-dimensional (3D) functional optoacoustic tomography (OAT), wavelength-dependent optical attenuation and nonuniform incident optical fluence limit imaging depth and field of view and can hinder accurate estimation of functional quantities, such as the vascular blood oxygenation. These limitations hinder OAT of large objects, such as a human female breast.
aimWe aim to develop a measurement-data-driven method for normalization of the optical fluence distribution and to investigate blood vasculature detectability and accuracy for estimating vascular blood oxygenation. APPROACH: The proposed method is based on reasonable assumptions regarding breast anatomy and optical properties. The nonuniform incident optical fluence is estimated based on the illumination geometry in the OAT system, and the depth-dependent optical attenuation is approximated using Beer-Lambert law.
resultsNumerical studies demonstrated that the proposed method significantly enhanced blood vessel detectability and improved estimation accuracy of the vascular blood oxygenation from multiwavelength OAT measurements, compared with direct application of spectral linear unmixing without optical fluence compensation. Experimental results showed that the proposed method revealed previously invisible structures in regions deeper than 15 mm and/or near the chest wall.
conclusionsThe proposed method provides a straightforward and computationally inexpensive approximation of wavelength-dependent effective optical attenuation and, thus, enables mitigation of the spectral coloring effect in functional 3D OAT imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.