ArticleAddiction (Abingdon, England)2022
The opioid use disorder core outcomes set (OUD-COS) for treatment research: findings from a Delphi consensus study.
Article in Addiction (Abingdon, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Substance Use Disorder Treatment Outcomes: Methodological Overview of Metrics and Criteria.International journal of methods in psychiatric research · 2025Pooled it
- From access to sustainability: understanding telemedicine-based buprenorphine induction through a RE-AIM lens.Addiction science & clinical practice · 2026Trial
- Lessons from COVID-19 for improving delivery of medications for opioid use disorder in future pandemic events: results from a Puerto Rico Delphi consensus panel.Harm reduction journal · 2026Article
- Duration of Methadone and Buprenorphine-Naloxone Treatment.JAMA network open · 2025Article
- Tools to implement measurement-based care (MBC) in the treatment of opioid use disorder (OUD): toward a consensus.Addiction science & clinical practice · 2024Article
- MOUD 2.0: a clinical algorithm and implementation evaluation protocol for sublingual and injectable buprenorphine treatment of opioid use disorder.Frontiers in psychiatry · 2024Article
- Moving towards a core measures set for patient safety in perioperative care: An e-Delphi consensus study.PloS one · 2024Article
- Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial.EClinicalMedicine · 2023Article
- Evaluation of randomized controlled trials: a primer and tutorial for mental health researchers.Trials · 2023Article
- A patient-centered nurse-supported primary care-based collaborative care program to treat opioid use disorder and depression: Design and protocol for the MI-CARE randomized controlled trial.Contemporary clinical trials · 2023Article
- The opioid use disorder core outcomes set (OUD-COS) for treatment research: findings from a Delphi consensus study.Addiction (Abingdon, England) · 2022Article
- Low-Threshold Buprenorphine in Non-Traditional Settings: A Scoping Review.Substance use : research and treatmentReview
- Secondary Analysis of Agreement Between Negative Timeline Follow Back Report and Negative Urine Toxicology in a Large Trial of Individuals with Opioid Use Disorder.Journal of addiction medicineArticle
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Authors and funding
23 authors at 16 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimThere is no gold-standard and considerable heterogeneity in outcome measures used to evaluate treatments for opioid use disorder (OUD) along the opioid treatment cascade. The aim of this study was to develop the US National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network (CTN) opioid use disorder core outcomes set (OUD-COS).
designFour-round, e-Delphi expert panel consensus study and plenary research group discussion and targeted consultation.
settingUnited States.
participantsA panel of 25 members including clinical practitioners, clinical researchers and administrative staff from the CTN, the network's affiliated clinical and community sites and the NIDA Centre for the CTN. MEASUREMENTS: From a pool of 24 candidate items in four domains (biomedical/disease status; behaviors, symptoms and functioning; opioid treatment cascade; and morbidity and mortality), the panel completed an on-line questionnaire to rank items with defined specification on a 9-point scale for importance, with a standard 70% consensus criterion.
findingsAfter the fourth round of the questionnaire and subsequent discussion, consensus was reached for five outcomes: two patient-reported (global impression of improvement and incident non-fatal overdose); one clinician-reported (illicit/non-medical drug toxicology); and two from administrative records (duration of treatment and fatal opioid poisoning).
conclusionsAn e-Delphi consensus study has produced the US National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network opioid use disorder core outcomes set (version 1) for opioid use disorder treatment efficacy and effectiveness research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.