ArticleJournal of clinical laboratory analysis2022
Serum lutein is a promising biomarker for type 2 diabetes mellitus and diabetic kidney disease in the elderly.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Rapid LC-MS/MS-based quantitative serum tryptophan metabolomics platform identifies and monitors novel biomarkers for diabetic kidney disease.Analytical and bioanalytical chemistry · 2026Article
- Lutein augments the hypoglycemic effect of metformin through the gut microbiota-imidazole propionate axis in type 2 diabetic model mice.Scientific reports · 2025Article
- An Overview on the Effects of Some Carotenoids on Health: Lutein and Zeaxanthin.Current nutrition reports · 2024Review
- Chronic Kidney Disease Diets for Kidney Failure Prevention: Insights from the IL-11 Paradigm.Nutrients · 2024Review
- Lutein-Rich Beverage Alleviates Visual Fatigue in the Hyperglycemia Model of Sprague-Dawley Rats.Metabolites · 2023Article
- A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases.International journal of molecular sciences · 2023Review
- Serum lutein is a promising biomarker for type 2 diabetes mellitus and diabetic kidney disease in the elderly.Journal of clinical laboratory analysis · 2022Article
- Novel biomarkers and therapeutic approaches for diabetic retinopathy and nephropathy: Recent progress and future perspectives.Frontiers in endocrinology · 2022Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the relationship between serum lutein and type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD) in elderly individuals.
methodsA total of 60 T2DM patients over 60 years were subgrouped into a DKD group and a non-DKD group according to their urinary microalbumin-to-creatinine ratio (UACR), while 30 age-matched non-T2DM patients were recruited in the control group. Baseline characteristics, laboratory examination results, and serum lutein levels were compared, and their correlations were analyzed. Receiver operating characteristic (ROC) curves were plotted to identify the diagnostic potential of lutein in T2DM and DKD.
resultsThe lutein level in the T2DM group was significantly lower than that in the control group and was also significantly lower in the DKD group than in the non-DKD group (p < 0.001). Lutein levels were negatively correlated with body mass index, glycosylated hemoglobin, fasting blood glucose, triglyceride, and UACR and positively correlated with high-density lipoprotein cholesterol (p < 0.05). T2DM patients were divided into four groups according to the quartile of their lutein level. The proportion of T2DM and DKD gradually decreased with increasing lutein levels (p < 0.001). The area under the ROC curve of serum lutein in diagnosing T2DM and DKD was 0.880 and 0.779, respectively, with corresponding cut-off values of 0.433 μmol/L and 0.197 μmol/L (p < 0.001).
conclusionThe serum level of lutein is negatively correlated with the incidence of T2DM and DKD in the elderly and can serve as a diagnostic marker for T2DM and DKD.
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