ArticleJournal of neuroscience research2022
DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging.
Article in Journal of neuroscience research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Aging-related vulnerability in dopamine-glutamate neurons weakens entorhinal dopamine signaling and underlies novelty discrimination deficits.Research square · 2026Article
- Evidence for age-related vulnerability in dopamine-glutamate projections to the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- Review
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A more objective PD diagnostic model: integrating texture feature markers of cerebellar gray matter and white matter through machine learning.Frontiers in aging neuroscience · 2024Article
- Widespread fMRI BOLD Signal Overactivations during Cognitive Control in Older Adults Are Not Matched by Corresponding Increases in fPET Glucose Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum.Aging brain · 2023Article
- Dopamine D1-signaling modulates maintenance of functional network segregation in aging.Aging brain · 2023Article
- DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging.Journal of neuroscience research · 2022Article
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Authors and funding
13 authors.
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Abstract
Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning the adult human lifespan. DyNAMiC examines age-related changes in the brain's structural and functional connectome in relation to changes in dopamine D1 receptor availability (D1DR), and their associations to cognitive decline. Critically, due to the complete lack of longitudinal D1DR data, the true trajectory of one of the most age-sensitive dopamine systems remains unknown. The first DyNAMiC wave included 180 healthy participants (20-80 years). Brain imaging included magnetic resonance imaging assessing brain structure (white matter, gray matter, iron), perfusion, and function (during rest and task), and positron emission tomography (PET) with the [
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