Evidence map›Paper›PMID 35292997›Full record

ArticleBiomedical chromatography : BMC2022

Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS method.

Divya Kumar Vemuri, Rambabu Gundla, Naresh Konduru, Ravindra Mallavarapu, Naresh Kumar Katari

Abstract read
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Article in Biomedical chromatography : BMC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Divya Kumar VemuriDepartment of Chemistry, School of Science, GITAM (Deemed to be University) Hyderabad, Hyderabad, India.
Rambabu GundlaDepartment of Chemistry, School of Science, GITAM (Deemed to be University) Hyderabad, Hyderabad, India.ORCID https://orcid.org/0000-0003-0390-6505
Naresh KonduruDepartment of Chemistry, School of Science, GITAM (Deemed to be University) Hyderabad, Hyderabad, India.ORCID https://orcid.org/0000-0003-0815-9238
Ravindra MallavarapuDepartment of Chemistry, School of Science, GITAM (Deemed to be University) Hyderabad, Hyderabad, India.
Naresh Kumar KatariDepartment of Chemistry, School of Science, GITAM (Deemed to be University) Hyderabad, Hyderabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Favipiravir finished dosage was approved for emergency use in many countries to treat SARS-CoV-2 patients. A specific, accurate, linear, robust, simple, and stability-indicating HPLC method was developed and validated for the determination of degradation impurities present in favipiravir film-coated tablets. The separation of all impurities was achieved from the stationary phase (Inert sustain AQ-C18, 250 × 4.6 mm, 5-μm particle) and mobile phase. Mobile phase A contained KH

Indexed as

COVID-19SARS-CoV-2AcetonitrilesAmidesChromatography, High Pressure LiquidChromatography, LiquidDrug ContaminationDrug StabilityHumansPyrazinesReproducibility of ResultsTandem Mass SpectrometryAcetonitrilesAmidesfavipiravirPyrazinesdegradation impurities, favipiravir, LC/LC-MS, related substances, SARS-CoV-2, stability indicating

Identifiers

PMID35292997
PMCPMC9073977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.