Evidence map›Paper›PMID 35292789›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2022

Chronic rhinosinusitis with nasal polyps: how to identify eligible patients for biologics in clinical practice.

Matteo Gelardi, Corso Bocciolini, Mario Notargiacomo, Irene Schiavetti, Cristiano Lingua, Pietro Pecoraro, Lucia Iannuzzi, Vitaliano Antonio Quaranta, Rossana Giancaspro, Gianluca Ronca and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. The nature of nasal discharge in chronic rhinosinusitis: a systematic review and meta-analysis using patient-reported outcomes.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Pooled it
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  5. Review
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  10. Sinonasal Symptoms in COPD: Burden and Associations with Clinical Markers of Disease.International journal of chronic obstructive pulmonary disease · 2022
    Article
  11. Histopathological parameters and immunoexpression of CD45RO (CLA) and CD68 in chronic rhinosinusitis with nasal polyps.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Matteo GelardiDepartment of Otolaryngology, University of Foggia, Italy.
Corso BoccioliniUOC of Otolaryngology Hospital Maggiore of Bologna, Italy.
Mario NotargiacomoOtorhinolaryngology Unit, Melzo Hospital, Milan, Italy.
Irene SchiavettiEpidemiology, Biostatistics and Committe, Department of Direction, Istituto Giannina Gaslini, Genoa, Italy.
Cristiano LinguaOtorhinolaryngology SC, ASO S, Croce and Carle, Cuneo, Italy.
Pietro PecoraroORL - Asp 6, Palermo, Italy.
Lucia IannuzziENT Clinic, Department of Biomedical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.
Vitaliano Antonio QuarantaPneumology Unity, Di Venere Hospital, Bari, Italy.
Rossana GiancasproDepartment of Otolaryngology, University of Foggia, Italy.
Gianluca RoncaDepartment of Otolaryngology, University of Foggia, Italy.
Michele CassanoDepartment of Otolaryngology, University of Foggia, Italy.
Giorgio CiprandiAllergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Italian Study Group on Nasal Polyps
University of Foggia · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITCasa di Cura Columbus · ITIstituto Giannina Gaslini · ITOspedale Maggiore Carlo Alberto Pizzardi · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study compared three severity measures for chronic rhinosinusitis with nasal polyps (CRSwNP). The outcome was to identify patients who are eligible for biological therapy. Methods: 330 adult patients with CRSwNP were examined. Nasal polyp score (NPS), sinonasal outcome test (SNOT-22) and clinical-cytological grading (CCG) were compared. Clinical history, past surgery and asthma control test were also considered. Results: Only 45 (13.6%) patients had a contextual positivity to the three severity measures. The concordance among tests was slight/fair. Patients with severe disease (all tests positive) had more impaired parameters. The mixed cytotype (OR = 4.07), nasal obstruction (OR = 10.06), post-nasal drip (OR = 1.98), embarrassment (OR = 2.53) and difficulty falling asleep (OR = 1.92) were significantly associated with severe CRSwNP. Conclusions: To identify candidates for biological therapy, the contextual use of NPS, SNOT-22 and CCG is preferable. In this way, global assessment of CRSwNP, including morphology, inflammation, comorbidity, symptoms and quality of life is possible.

Indexed as

Biological ProductsNasal PolypsRhinitisSinusitisAdultHumansQuality of LifeBiological Productsbiological therapyCCGchronic rhinosinusitis with nasal polypsnasal polyp scoreSNOT-22

Identifiers

PMID35292789
PMCPMC9058935
OpenAlexW4220908304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.