ArticleScientific reports2022
Synergistic effects of carvacrol, α-terpinene, γ-terpinene, ρ-cymene and linalool against Gardnerella species.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- GC-MS Analyses and Bioactivity Evaluation of Origanum minutiflorum Essential Oil: Antioxidant, Antibacterial, Genotoxicity, and Molecular Docking Studies.Chemistry & biodiversity · 2026Article
- Comparative Analysis of Chemical Composition and Bioactivities of Volatile Oils FromFood science & nutrition · 2026Article
- Review
- Sustainable camel meat preservation using individual and synergistic essential oil bioactive compounds against Listeria monocytogenes.Scientific reports · 2026Article
- Chemical Profiling and Cheminformatic Insights intoMolecules (Basel, Switzerland) · 2026Article
- Integrated study of rhizosphere microbiome and metabolome profiles across tropical plantations in the Western Ghat regions of Kerala and Tamil Nadu, India.Frontiers in microbiology · 2026Article
- Analysis of Pharmacological Properties ofLife (Basel, Switzerland) · 2025Review
- Natural Molecules, Nutraceuticals, and Engineered Nanosystems: A Comprehensive Strategy for CombatingMicroorganisms · 2025Review
- Variability in seed essential oil composition of the cultivated Satureja hortensis L. (Lamiaceae) populations in Iran.BMC plant biology · 2025Article
- Investigation of differential Multi-Mode antibacterial mechanisms of essential oils of Satureja montana L. and Leptospermum scoparium J.R.Forst. & G.Forst. Against Porphyromonas gingivalis.BMC complementary medicine and therapies · 2025Article
- Chemical Composition and Synergistic Antimicrobial Effects of Essential Oils From Four Commonly Used Satureja Species in Combination With Two Conventional Antibiotics.Chemistry & biodiversity · 2025Article
- Antimicrobial Activity of Cinnamon, Tea Tree, and Thyme Essential Oils Against Pathogenic Bacteria Isolated from Tilapia (Molecules (Basel, Switzerland) · 2025Article
- Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance ofMolecules (Basel, Switzerland) · 2025Review
- Synergistic anti-biofilm strategy based on essential oils and its application in the food industry.World journal of microbiology & biotechnology · 2025Review
- Phytochemical characterization and multifaceted bioactivity assessment of essential oil fromHeliyon · 2024Article
- Combined effect of Tetracycline compounds and essential oils on antimicrobial resistantFrontiers in microbiology · 2024Article
- Growth inhibitory, immunosuppressive, cytotoxic, and genotoxic effects of γ-terpinene on Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae).Scientific reports · 2023Article
- Potential of Selected African Medicinal Plants as Alternative Therapeutics against Multi-Drug-Resistant Bacteria.Biomedicines · 2023Review
- Antibiofilm Effect ofPharmaceutics · 2023Article
- Fighting polymicrobial biofilms in bacterial vaginosis.Microbial biotechnology · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial vaginosis (BV) is the most common vaginal infection affecting women worldwide. This infection is characterized by the loss of the dominant Lactobacillus community in the vaginal microbiota and an increase of anaerobic bacteria, that leads to the formation of a polymicrobial biofilm, mostly composed of Gardnerella spp. Treatment of BV is normally performed using broad-spectrum antibiotics, such as metronidazole and clindamycin. However, the high levels of recurrence of infection after treatment cessation have led to a demand for new therapeutic alternatives. Thymbra capitata essential oils (EOs) are known to have a wide spectrum of biological properties, including antibacterial activity. Thus, herein, we characterized two EOs of T. capitata and tested their antimicrobial activity as well as some of their main components, aiming to assess possible synergistic effects. Our findings showed that carvacrol and ρ-cymene established a strong synergistic antimicrobial effect against planktonic cultures of Gardnerella spp. On biofilm, carvacrol and linalool at sub-MIC concentrations proved more efficient in eliminating biofilm cells, while showing no cytotoxicity observed in a reconstituted human vaginal epithelium. The antibiofilm potential of the EOs and compounds was highlighted by the fact cells were not able to recover culturability after exposure to fresh medium.
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