ArticleNature communications2022
Tau deposition patterns are associated with functional connectivity in primary tauopathies.
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In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.Acta neuropathologica communications · 2024Pooled it
- Pooled it
- Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Whole-body TSPO-PET reveals stage-dependent disruption of systemic immune organ interactions in glioblastoma.European journal of nuclear medicine and molecular imaging · 2026Article
- Regional brain metabolism and metabolic connectivity alterations in corticobasal syndrome assessed with [European journal of nuclear medicine and molecular imaging · 2026Article
- Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Dynamic [Molecular neurodegeneration · 2026Article
- Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes.Brain : a journal of neurology · 2026Article
- Tau seeds induce neurofibrillary tangle formation across brain regions via individual-specific connectivity.Neuron · 2026Article
- tRNA-derived fragments elevated in Alzheimer's disease promote Tau aggregation.bioRxiv : the preprint server for biology · 2026Article
- Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.Science advances · 2026Article
- Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy.Annals of clinical and translational neurology · 2026Article
- The degenerome-a novel streamline-wise approach for white matter integrity in neurodegeneration.NPJ Parkinson's disease · 2026Article
- Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.Communications biology · 2026Article
- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease.Research square · 2026Article
- Regional correlates of tau pathology and synaptic function in primary age-related tauopathy.Journal of Alzheimer's disease : JAD · 2026Article
- Algebraic Connectivity Reveals Modulated High-Order Functional Networks in Alzheimer's Disease.ArXiv · 2026Article
- Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 16 institutions in 9 countries.
Nicolai Franzmeier *Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany. Nicolai.franzmeier@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-9736-2283
Matthias Brendel *Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-9247-2843
Leonie BeyerDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7358-4495
Luna SlemannDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Gabor G KovacsCenter for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3841-5511
Thomas ArzbergerMunich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Carolin KurzGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Gesine RespondekGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Milica J LukicGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Davina BielInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.
Anna RubinskiInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.
Lukas FrontzkowskiInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.
Selina HummelDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Andre MüllerLife Molecular Imaging GmbH, Berlin, Germany.
Anika FinzeDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-3966-5814
Carla PalleisMunich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Emanuel JosephDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Endy WeidingerDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Sabrina KatzdoblerDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-3512-5984
Mengmeng SongDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Gloria BiecheleDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Maike KernDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Maximilian ScheifeleDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Boris-Stephan RauchmannDepartment of Radiology, University Hospital of Munich, LMU Munich, Munich, Germany.
Robert PerneczkyMunich Cluster for Systems Neurology (SyNergy), Munich, Germany.ORCID http://orcid.org/0000-0003-1981-7435
Michael RullmanDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Marianne PattDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Andreas SchildanDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-9418-3826
Henryk BarthelDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Osama SabriDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Jost J RumpfDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Matthias L SchroeterDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Joseph ClassenDepartment of Neurology, University Hospital Leipzig, Leipzig, Germany.
Victor VillemagneDepartment of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.
John SeibylInviCRO, LLC, Boston, MA, USA.
Andrew W StephensLife Molecular Imaging GmbH, Berlin, Germany.ORCID http://orcid.org/0000-0001-5052-6586
Edward B LeeCenter for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David G CoughlinFrontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4111-0102
Armin GieseCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Murray GrossmanFrontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA.
Corey T McMillanFrontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA.
Ellen GelpiNeurological Tissue Bank and Neurology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CERCA, Barcelona, Catalonia, Spain.
Laura Molina-PorcelNeurological Tissue Bank and Neurology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CERCA, Barcelona, Catalonia, Spain.ORCID http://orcid.org/0000-0003-4068-8578
Yaroslau ComptaParkinson's Disease & Movement Disorders Unit, Hospital Clínic / IDIBAPS / CIBERNED (CB06/05/0018-ISCIII), / European Reference Network for Rare Neurological Diseases (ERN-RND) / Institut de Neurociències (Maria de Maeztu Center), Universitat de Barcelona, Barcelona, Catalonia, Spain.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Laura Donker LaatDepartment Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Claire TroakesLondon Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.ORCID http://orcid.org/0000-0002-1790-7376
Safa Al-SarrajLondon Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
John L RobinsonCenter for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
David J IrwinDepartment of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5599-5098
Sigrun RoeberCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Jochen HermsGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID http://orcid.org/0000-0002-6201-1042
Mikael SimonsGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Virginia M LeeCenter for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9239-8794
Johannes LevinMunich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Günter HöglingerGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID http://orcid.org/0000-0001-7587-6187
Michael EwersInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-5231-1714
LMU Klinikum · DEGerman Center for Neurodegenerative Diseases · DEUniversity Hospital Leipzig · DELudwig-Maximilians-Universität München · DEInstitute on Aging · USUniversity of Pennsylvania · USHospital Clínic de Barcelona · ESKing's College London · GBErasmus MC · NLErasmus University Rotterdam · NLInstituto de Salud Carlos III · ESInvicro (United States) · USThe University of Melbourne · AUTUM Klinikum · DEUniversity Health Network · CAUniversity of California San Diego · US
Funding
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1MResearch Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo · 2020 to 2026
$18.8MProject IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WEINTRAUB, DANIEL · 2019 to 2023
$18.1MNRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0MMicroscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar DegenerationR01NS109260 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2019 to 2023
$3.8MPathological and cognitive correlations of real time quaking induced conversion in LBD and ADK23NS120038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COUGHLIN, DAVID G · 2021 to 2025
$828kNCATS NIH HHS TL1 TR001880NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG072979NIA NIH HHS U19 AG062418NINDS NIH HHS K23 NS120038NINDS NIH HHS R01 NS109260
Abstract
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2
Indexed as
Supranuclear Palsy, ProgressiveTauopathiesBrainHumansMagnetic Resonance Imagingtau Proteinstau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.