Evidence map›Paper›PMID 35292538›Full record

ArticleLife science alliance2022

Structure and conformational dynamics of

Baohua Chen, Sujit Basak, Peng Chen, Changcheng Zhang, Kay Perry, Songhai Tian, Clinton Yu, Min Dong, Lan Huang, Mark E Bowen and 1 more

Abstract read
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Mechanisms ofFrontiers in cellular and infection microbiology · 2025
    Review
  4. Clinical microbiology reviews · 2024
    Review
  5. Toxins · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Structure-guided design of a potentFrontiers in microbiology · 2023
    Article
  12. Neutralizing epitopes onFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Baohua ChenDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Sujit BasakDepartment of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0002-9845-6326
Peng ChenDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-6356-7683
Changcheng ZhangDepartment of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA.
Kay PerryNE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, IL, USA.
Songhai TianDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6630-1904
Clinton YuDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Min DongDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Lan HuangDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Mark E BowenDepartment of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA r.jin@uci.edu mark.bowen@stonybrook.edu.ORCID 0000-0002-9525-6986
Rongsheng JinDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA r.jin@uci.edu mark.bowen@stonybrook.edu.ORCID 0000-0003-0348-7363

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Structure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4M
Proteomics of the Proteasome Interacting NetworksR01GM074830 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2005 to 2022
$6.1M
SINGLE MOLECULE ANALYSIS OF PSD-95 STRUCTURE AND LIGAND BINDINGR01MH081923 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI BOWEN, MARK E · 2008 to 2022
$5.6M
Developing broad-spectrum therapeutics against C. difficile toxinsR01AI158503 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2025
$3.9M
Molecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5M
Molecular mechanisms of botulinum neurotoxin neutralizationR01AI125704 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG, SHOEMAKER, CHARLES BIX · 2016 to 2020
$3.0M
Resolving the intoxication mechanism of botulinum neurotoxins using single molecule structural biologyR01GM151334 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Mark E Bowen · 2023 to 2026
$1.4M
Structural dynamics and function of the COP9 signalosomeR01GM130144 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2018 to 2021
$1.2M
Structural basis of Rho glucosylation by Clostridium difficile toxinsR21AI156092 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432k
Structural basis for recognition of SV2 by type E botulinum neurotoxinR21AI163178 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2021 to 2022
$432k
NIAID NIH HHS R01 AI125704NIAID NIH HHS R01 AI132387NIAID NIH HHS R01 AI139087NIAID NIH HHS R01 AI158503NIAID NIH HHS R21 AI156092NIAID NIH HHS R21 AI163178NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM074830NIGMS NIH HHS R01 GM130144NIGMS NIH HHS R01 GM151334NIMH NIH HHS R01 MH081923
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ToxinsClostridioides difficileBacterial ProteinsMolecular ConformationBacterial ProteinsBacterial Toxins

Identifiers

PMID35292538
PMCPMC8924006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.