Evidence map›Paper›PMID 35292069›Full record

ArticleAIDS research and therapy2022

HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data).

Tangui Barré, Patrick Mercié, Caroline Lions, Patrick Miailhes, David Zucman, Hugues Aumaître, Laure Esterle, Philippe Sogni, Patrizia Carrieri, Dominique Salmon-Céron and 2 more

Open access · goldAbstract read
In one paragraph

Article in AIDS research and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Tangui BarréAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France.
Patrick MerciéCentre Hospitalier Universitaire (CHU) de Bordeaux, Pôle Médecine Interne, Service de Médecine Interne et Immunologie Clinique, Bordeaux Population Health Research Center UMR 1219, CIC-EC 1401, Université de Bordeaux, Pl. Amélie Raba Léon, 33000, Bordeaux, France.
Caroline LionsAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France.
Patrick MiailhesCentre Hospitalier de Bourg-en-Bresse, Service d'Infectiologie, 900 Rte de Paris, 01012, Bourg-en-Bresse, France.
David ZucmanRéseau Ville-Hôpital, Service de Médecine Interne, Foch Hospital, 40 Rue Worth, 92150, Suresnes, France.
Hugues AumaîtreCentre Hospitalier de Perpignan, Service des Maladies Infectieuses et Tropicales, 20 Av. du Languedoc, 66000, Perpignan, France.
Laure EsterleISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, Université de Bordeaux, 146 Rue Léo Saignat 11, Bordeaux, France.
Philippe SogniUniversité Paris Descartes, 12 Rue de l'École de Médecine, 75006, Paris, France.
Patrizia CarrieriAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France. pmcarrieri@aol.com.
Dominique Salmon-CéronUniversité Paris Descartes, 12 Rue de l'École de Médecine, 75006, Paris, France.
Fabienne MarcellinAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France.
ANRS CO13 HEPAVIH Study Group
Hôpital Cochin · FRInserm · FRHôpital Foch · FRUniversité de Bordeaux · FRDélégation Paris 5 · FRInt'Air Medical (France) · FRCentre Hospitalier de Perpignan · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThanks to direct-acting antivirals, hepatitis C virus (HCV) infection can be cured, with similar rates in HCV-infected and HIV-HCV co-infected patients. HCV cure is likely to foster behavioral changes in psychoactive substance use, which is highly prevalent in people living with HIV (PLWH). Cannabis is one substance that is very commonly used by PLWH, sometimes for therapeutic purposes. We aimed to identify correlates of cannabis use reduction following HCV cure in HIV-HCV co-infected cannabis users and to characterize persons who reduced their use.

methodsWe used data collected on HCV-cured cannabis users in a cross-sectional survey nested in the ANRS CO13 HEPAVIH cohort of HIV-HCV co-infected patients, to perform logistic regression, with post-HCV cure cannabis reduction as the outcome, and socio-behavioral characteristics as potential correlates. We also characterized the study sample by comparing post-cure substance use behaviors between those who reduced their cannabis use and those who did not.

resultsAmong 140 HIV-infected cannabis users, 50 and 5 had reduced and increased their use, respectively, while 85 had not changed their use since HCV cure. Cannabis use reduction was significantly associated with tobacco use reduction, a decrease in fatigue level, paying more attention to one's dietary habits since HCV cure, and pre-HCV cure alcohol abstinence (p = 0.063 for alcohol use reduction).

conclusionsAmong PLWH using cannabis, post-HCV cure cannabis reduction was associated with tobacco use reduction, improved well-being, and adoption of healthy behaviors. The management of addictive behaviors should therefore be encouraged during HCV treatment.

Indexed as

CannabisCoinfectionHepatitis CHepatitis C, ChronicHIV InfectionsSubstance-Related DisordersAntiviral AgentsCross-Sectional StudiesHepacivirusHumansAntiviral AgentsBehavioral changesCannabisHCV cureHepatitis CHIVMarijuanaSmokingSustained virological response

Identifiers

PMID35292069
PMCPMC8922772
OpenAlexW4221041777

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.